[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, MUTAGENESIS OF ALA-183, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
PubMed=9716402 [NCBI, ExPASy, EBI, Israel, Japan]
Paradis S.,
Ruvkun G.;
"Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor.";
Genes Dev. 12:2488-2498(1998).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
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[3]
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FUNCTION.
PubMed=10364160 [NCBI, ExPASy, EBI, Israel, Japan]
Paradis S.,
Ailion M.,
Toker A.,
Thomas J.H.,
Ruvkun G.;
"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans.";
Genes Dev. 13:1438-1452(1999).
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[4]
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FUNCTION.
DOI=10.1016/S0960-9822(01)00594-2; PubMed=11747825 [NCBI, ExPASy, EBI, Israel, Japan]
Henderson S.T.,
Johnson T.E.;
"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans.";
Curr. Biol. 11:1975-1980(2001).
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[5]
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FUNCTION.
DOI=10.1038/88850; PubMed=11381260 [NCBI, ExPASy, EBI, Israel, Japan]
Lin K.,
Hsin H.,
Libina N.,
Kenyon C.;
"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling.";
Nat. Genet. 28:139-145(2001).
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[6]
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INTERACTION WITH PDK-1; SGK-1; AKT-2 AND DAF-16, AND FUNCTION.
DOI=10.1016/S1534-5807(04)00095-4; PubMed=15068796 [NCBI, ExPASy, EBI, Israel, Japan]
Hertweck M.,
Goebel C.,
Baumeister R.;
"C. elegans SGK-1 is the critical component in the Akt/PKB kinase complex to control stress response and life span.";
Dev. Cell 6:577-588(2004).
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- FUNCTION: Acts downstream age-1 and pdk-1 in the daf-2/insulin receptor-like transduction pathway, which controls longevity and prevents developmental arrest at the dauer stage. Phosphorylates Forkhead-related daf-16 transcription factor, which inhibits its entry into the nucleus and antagonizes its function.
- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
- SUBUNIT: Interacts with pdk-1, sgk-1, akt-2 and daf-16. Part of a complex containing sgk-1, akt-1 and akt-2.
- INTERACTION:
O18676:daf-16; NbExp=1; IntAct=EBI-1770718, EBI-1770827;
P34707-1:skn-1; NbExp=1; IntAct=EBI-1770718, EBI-434984;
P34707-3:skn-1; NbExp=1; IntAct=EBI-1770718, EBI-434993;
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
- TISSUE SPECIFICITY: Expressed in neurons, muscle cells of the pharynx, rectal gland cells, and spermatheca.
- DEVELOPMENTAL STAGE: Expressed in late stage embryos and throughout life.
- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.
- SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
- SIMILARITY: Contains 1 PH domain.
- SIMILARITY: Contains 1 protein kinase domain.
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