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UniProtKB/Swiss-Prot entry Q17693

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTHR_CAEEL
Primary accession number Q17693
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on June 20, 2002 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 51)
Name and origin of the protein
Protein name Probable methylenetetrahydrofolate reductase
Synonym EC 1.5.1.20
Gene name
ORFNames: C06A8.1
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U39849; AAA81048.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T15423; T15423.
RefSeq NP_741027.1; -.
UniGene Cel.17243
3D structure databases
HSSP P00394; 1B5T. [HSSP ENTRY / PDB]
ModBase Q17693.
Protein-protein interaction databases
IntAct Q17693; 3.
Organism-specific databases
WormBase WBGene00015512; C06A8.1.
WormPep C06A8.1; CE30593. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q17693; -.
Ontologies
GO
GO:0004489; Molecular function: methylenetetrahydrofolate reductase (NADPH) activity (inferred from electronic annotation from InterPro).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006555; Biological process: methionine metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR004621; Fadh2_euk.
IPR003171; Mehydrof_redctse.
Graphical view of domain structure.
Pfam PF02219; MTHFR; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00677; fadh2_euk; 1.
Genome annotation databases
Ensembl C06A8.1; Caenorhabditis elegans. [Contig view]
GeneID 174254; -.
KEGG cel:C06A8.1; -.
Other
NextBio 883243; -.
ProtoNet Q17693.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; FAD; Flavoprotein; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   663  663     Probable methylenetetrahydrofolate reductase. PRO_0000190248
Sequence information
Length: 663 AA [This is the length of the unprocessed precursor] Molecular weight: 75487 Da [This is the MW of the unprocessed precursor] CRC64: EA94806A2C3BC1CD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTNTGETKVI ESHGTIKKID SLSTMPYCGV ETDENAVVEE KITLESGKSW SPKHYELLHE 

        70         80         90        100        110        120 
RIERLIDEKQ QFFSLEFFPP RFVNGVPNFL ERVERLSEGG SVFVDMTWHM GSDPANVDKV 

       130        140        150        160        170        180 
TSSSSIAASM LDYCGVDTML HMTCVQYNKA DTLKHLEQAK AMGLRSILAL RGDLPPGTEL 

       190        200        210        220        230        240 
EDTHQFRALD MIRWIREEYG NYFSIGCAGY PLGHPQAPSY KADLMYLKAK CDAGANFVIT 

       250        260        270        280        290        300 
QLFFEAETFE KFVRDCREIG ITQPIIPGIM PIMGYESIKR IAKLSQLEIP QHILDDLEPI 

       310        320        330        340        350        360 
KHDDDAVQKY GTERCIEMCR RLLDNGTAPS IHLYTMNREG SIREILKSLG LWKLEGDRVF 

       370        380        390        400        410        420 
PWKNRSQHPI RCLESVRPIY WSFRPRSYIT RTRDWDQFPN GRWGNSSSPA FGDVSSYYLS 

       430        440        450        460        470        480 
NLTTVRNADD RLAMFGANIE SFEDVKRVFI NYITQAPNAD GVKVTVLPWT EAETGVQPET 

       490        500        510        520        530        540 
SLISEQLVWC NENGILTVNS QPSVNGAPST DPLVGWGKPG GYCYQKAYLE CFMTAELSDK 

       550        560        570        580        590        600 
LIQIIEREFP VRVNYHAINK DSTFDKTNSE ETTPIAVTWG VFPGSEIAQP TVVDPLSFRA 

       610        620        630        640        650        660 
WRDEAYQMWM AQWGDFYPKE SKSYGVIKAV HDEFRLVTLV DNDFQKPSVL FDVLQKALDE 


LKK
Q17693 in FASTA format

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