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UniProtKB/Swiss-Prot entry Q17334

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ADH1_CAEEL
Primary accession number Q17334
Secondary accession number O45688
Integrated into Swiss-Prot on May 30, 2000
Sequence was last modified on May 30, 2000 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 64)
Name and origin of the protein
Protein name Alcohol dehydrogenase 1
Synonyms EC 1.1.1.1
Sorbitol dehydrogenase family protein 1
Gene name
Name: sodh-1
ORFNames: K12G11.3
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 111-349.
DOI=10.1007/BF00174040; PubMed=7608988 [NCBI, ExPASy, EBI, Israel, Japan]
Glasner J.D., Kocher T.D., Collins J.J.;
"Caenorhabditis elegans contains genes encoding two new members of the Zn-containing alcohol dehydrogenase family.";
J. Mol. Evol. 41:46-53(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
Z81570; CAB04604.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U18780; AAB03373.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T23626; T23626.
RefSeq NP_505991.1; -.
UniGene Cel.23484
3D structure databases
ModBase Q17334.
Protein-protein interaction databases
DIP DIP:26303N; -.
IntAct Q17334; 4.
Organism-specific databases
WormBase WBGene00010790; sodh-1.
WormPep K12G11.3; CE12212. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q17334; -.
Ontologies
GO
GO:0004022; Molecular function: alcohol dehydrogenase activity (inferred from electronic annotation from EC).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0008270; Molecular function: zinc ion binding (inferred from electronic annotation from InterPro).
GO:0008340; Biological process: determination of adult life span (inferred from mutant phenotype from WormBase).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
Genome annotation databases
Ensembl K12G11.3; Caenorhabditis elegans. [Contig view]
GeneID 179627; -.
KEGG cel:K12G11.3; -.
Other
NextBio 906202; -.
ProtoNet Q17334.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   349  349     Alcohol dehydrogenase 1. PRO_0000160693
NP_BIND   180   186  7     NAD (By similarity). 
NP_BIND   270   272  3     NAD (By similarity). 
COMPBIAS   149   152  4     Poly-Ala. 
METAL   46    46        Zinc 1; catalytic (By similarity). 
METAL   69    69        Zinc 1; catalytic (By similarity). 
METAL   100   100        Zinc 2 (By similarity). 
METAL   103   103        Zinc 2 (By similarity). 
METAL   106   106        Zinc 2 (By similarity). 
METAL   114   114        Zinc 2 (By similarity). 
METAL   156   156        Zinc 1; catalytic (By similarity). 
BINDING   204   204        NAD (By similarity). 
BINDING   208   208        NAD (By similarity). 
BINDING   342   342        NAD (By similarity). 
CONFLICT   111   112        EP -> DA (in Ref. 2; AAB03373). 
CONFLICT   207   207        S -> R (in Ref. 2; AAB03373). 
CONFLICT   248   248        A -> G (in Ref. 2; AAB03373). 
CONFLICT   307   307        M -> I (in Ref. 2; AAB03373). 
CONFLICT   344   344        V -> G (in Ref. 2; AAB03373). 
Sequence information
Length: 349 AA [This is the length of the unprocessed precursor] Molecular weight: 37697 Da [This is the MW of the unprocessed precursor] CRC64: 94B2752CFCAC977E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTVELPSTQR ALVFDTWNGP LEVRQVPVPS PADDEILVKI EYSGICHSDL HVWLGDLKDM 

        70         80         90        100        110        120 
SVCPLVGGHE GAGSVVQIGK NVTGWQLGDK AGVKLMNFNC LNCEFCKKGH EPLCHHIQNY 

       130        140        150        160        170        180 
GFDRSGTFQE YLTIRGVDAA KINKDTNLAA AAPILCAGVT VYKALKESNV APGQIIVLTG 

       190        200        210        220        230        240 
AGGGLGSLAI QYACAMGMRV VAMDHGSKEA HCKGLGAEWF VDAFETPDIV SHITKLTEGG 

       250        260        270        280        290        300 
PHGVINFAVA RKPMEQAVEY VRKRGTVVFV GLPKDSKVTF DTTPFIFNAI TIKGSIVGSR 

       310        320        330        340 
LDVDEAMEFV TRGIVKVPLE LVKLEDVPAV YQRMLDGKIN SRAVVDFSL
Q17334 in FASTA format

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