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UniProtKB/Swiss-Prot entry Q16798

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAON_HUMAN
Primary accession number Q16798
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 25, 2008 (Sequence version 2)
Annotations were last modified on    December 16, 2008 (Entry version 75)
Name and origin of the protein
Protein name NADP-dependent malic enzyme, mitochondrial [Precursor]
Synonyms NADP-ME
EC 1.1.1.40
Malic enzyme 3
Gene name
Name: ME3
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT ASN-324.
TISSUE=Hippocampus;
PubMed=7818469 [NCBI, ExPASy, EBI, Israel, Japan]
Loeber G., Maurer-Fogy I., Schwendenwein R.;
"Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme.";
Biochem. J. 304:687-692(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nature04632; PubMed=16554811 [NCBI, ExPASy, EBI, Israel, Japan]
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G., Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.;
"Human chromosome 11 DNA sequence and analysis including novel gene identification.";
Nature 440:497-500(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X79440; CAA55956.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AP001148; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AP001831; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
AP002492; -; NOT_ANNOTATED_CDS; Genomic_DNA.[EMBL / GenBank / DDBJ]
PIR S53351; S53351.
RefSeq NP_001014811.1; -.
NP_006671.2; -.
UniGene Hs.199743
3D structure databases
HSSP P40927; 1GQ2. [HSSP ENTRY / PDB]
ModBase Q16798.
PTM databases
PhosphoSite Q16798; -.
Organism-specific databases
GeneCards GC11M085829; -.
H-InvDB HIX0010004; -.
HGNC HGNC:6985; ME3.
GenAtlas ME3.
MIM 604626; gene. [NCBI / EBI]
PharmGKB PA30725; -.
GeneCards Q16798.
Gene expression databases
ArrayExpress Q16798; -.
CleanEx HS_ME3; -.
GermOnline ENSG00000151376; Homo sapiens.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
GO:0004473; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity (inferred from direct assay from UniProtKB).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (traceable author statement from UniProtKB).
GO:0006108; Biological process: malate metabolic process (inferred from direct assay from UniProtKB).
GO:0055114; Biological process: oxidation reduction (inferred from direct assay from UniProtKB).
GO:0006800; Biological process: oxygen and reactive oxygen species metabolic process (traceable author statement from UniProtKB).
GO:0006090; Biological process: pyruvate metabolic process (inferred from direct assay from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
Genome annotation databases
Ensembl ENSG00000151376; Homo sapiens. [Contig view]
GeneID 10873; -.
Phylogenomic databases
HOGENOM Q16798; -.
HOVERGEN Q16798; -.
Other
DrugBank DB00157; NADH.
NextBio 41285; -.
SOURCE ME3; Homo sapiens.
ProtoNet Q16798.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Metal-binding; Mitochondrion; NADP; Oxidoreductase; Polymorphism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   604        NADP-dependent malic enzyme, mitochondrial. PRO_0000018539
ACT_SITE   137   137        Proton donor (By similarity). 
ACT_SITE   208   208        Proton acceptor (By similarity). 
METAL   280   280        Divalent metal cation (By similarity). 
METAL   281   281        Divalent metal cation (By similarity). 
METAL   304   304        Divalent metal cation (By similarity). 
BINDING   190   190        NAD (By similarity). 
BINDING   304   304        NAD (By similarity). 
BINDING   443   443        NAD (By similarity). 
SITE   304   304  1     Important for activity (By similarity). 
VARIANT   85    85  1     S -> G (in dbSNP:rs17856661 [NCBI]). VAR_047369 [3D]
VARIANT   324   324  1     K -> N (in dbSNP:rs1042780 [NCBI]). VAR_047370 [3D]
Sequence information
Length: 604 AA [This is the length of the unprocessed precursor] Molecular weight: 67068 Da [This is the MW of the unprocessed precursor] CRC64: E0E79A75F3CAC524 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGAALGTGTR LAPWPGRACG ALPRWTPTAP AQGCHSKPGP ARPVPLKKRG YDVTRNPHLN 

        70         80         90        100        110        120 
KGMAFTLEER LQLGIHGLIP PCFLSQDVQL LRIMRYYERQ QSDLDKYIIL MTLQDRNEKL 

       130        140        150        160        170        180 
FYRVLTSDVE KFMPIVYTPT VGLACQHYGL TFRRPRGLFI TIHDKGHLAT MLNSWPEDNI 

       190        200        210        220        230        240 
KAVVVTDGER ILGLGDLGCY GMGIPVGKLA LYTACGGVNP QQCLPVLLDV GTNNEELLRD 

       250        260        270        280        290        300 
PLYIGLKHQR VHGKAYDDLL DEFMQAVTDK FGINCLIQFE DFANANAFRL LNKYRNKYCM 

       310        320        330        340        350        360 
FNDDIQGTAS VAVAGILAAL RITKNKLSNH VFVFQGAGEA AMGIAHLLVM ALEKEGVPKA 

       370        380        390        400        410        420 
EATRKIWMVD SKGLIVKGRS HLNHEKEMFA QDHPEVNSLE EVVRLVKPTA IIGVAAIAGA 

       430        440        450        460        470        480 
FTEQILRDMA SFHERPIIFA LSNPTSKAEC TAEKCYRVTE GRGIFASGSP FKSVTLEDGK 

       490        500        510        520        530        540 
TFIPGQGNNA YVFPGVALGV IAGGIRHIPD EIFLLTAEQI AQEVSEQHLS QGRLYPPLST 

       550        560        570        580        590        600 
IRDVSLRIAI KVLDYAYKHN LASYYPEPKD KEAFVRSLVY TPDYDSFTLD SYTWPKEAMN 


VQTV
Q16798 in FASTA format

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