[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1084/jem.183.6.2593; PubMed=8676080 [NCBI, ExPASy, EBI, Israel, Japan] Fossiez F., Djossou O., Chomarat P., Flores-Romo L., Ait-Yahia S., Maat C., Pin J.-J., Garrone P., Garcia E., Saeland S., Blanchard D., Gaillard C., Das Mahapatra B., Rouvier E., Golstein P., Banchereau J., Lebecque S.; "T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines."; J. Exp. Med. 183:2593-2603(1996).
[2]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=T-cell; PubMed=7499828 [NCBI, ExPASy, EBI, Israel, Japan] Yao Z., Painter S.L., Fanslow W.C., Ulrich D., Macduff B.M., Spriggs M.K., Armitage R.J.; "Human IL-17: a novel cytokine derived from T cells."; J. Immunol. 155:5483-5486(1995).
[3]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. SeattleSNPs program for genomic applications; Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).
[5]	PROTEIN SEQUENCE OF 24-38. DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan] Zhang Z., Henzel W.J.; "Signal peptide prediction based on analysis of experimentally verified cleavage sites."; Protein Sci. 13:2819-2824(2004).

Comments

FUNCTION: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Restricted to activated memory T-cells.
PTM: Found both in glycosylated and nonglycosylated forms.
SIMILARITY: Belongs to the IL-17 family.
WEB RESOURCE: Name=R&D Systems' cytokine mini-reviews: IL-17; URL="http://www.rndsystems.com/molecule_detail.aspx?m=1674";.
WEB RESOURCE: Name=Wikipedia; Note=Interleukin-17 entry; URL="http://en.wikipedia.org/wiki/Interleukin_17";.
WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il17/";.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z58820; CAA91233.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
U32659; AAC50341.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY460616; AAR23263.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066251; AAH66251.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066252; AAH66252.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067503; AAH67503.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067504; AAH67504.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC067505; AAH67505.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_002181.1; -.

UniGene

Hs.41724

3D structure databases

HSSP

Q96PD4; 1JPY. [HSSP ENTRY / PDB]

ModBase

Q16552.

Protein-protein interaction databases

DIP

DIP:6014N; -.

Organism-specific databases

HIX0032919; -.

HGNC:5981; IL17A.

603149; gene. [NCBI / EBI]

GeneCards

Q16552.

Gene expression databases

ArrayExpress

Q16552; -.

CleanEx

HS_IL17A; -.

GermOnline

ENSG00000112115; Homo sapiens.

Ontologies

GO:0005615;	Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0005125;	Molecular function: cytokine activity (traceable author statement from ProtInc).
GO:0006915;	Biological process: apoptosis (traceable author statement from ProtInc).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0006955;	Biological process: immune response (traceable author statement from ProtInc).
GO:0006486;	Biological process: protein amino acid glycosylation (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR010345; IL17.
Graphical view of domain structure.

PANTHER

PTHR21295; IL17; 1.

Pfam

PF06083; IL17; 1.
Pfam graphical view of domain structure.

BLOCKS

Q16552.

Genome annotation databases

Ensembl

ENSG00000112115; Homo sapiens. [Contig view]

GeneID

3605; -.

KEGG

hsa:3605; -.

Phylogenomic databases

HOGENOM

Q16552; -.

HOVERGEN

Q16552; -.

Other

IL17A; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytokine; Direct protein sequencing; Glycoprotein; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 23`	`23`
`CHAIN`	`24 155`	`132`	`Interleukin-17A.`	`PRO_0000015423`
`CARBOHYD`	`68 68`		`N-linked (GlcNAc...) (Potential).`
`DISULFID`	`94 144`		`By similarity.`
`DISULFID`	`99 146`		`By similarity.`

Sequence information

Length: 155 AA [This is the length of the unprocessed precursor]

Molecular weight: 17504 Da [This is the MW of the unprocessed precursor]

CRC64: 2BCAE9CB2F4886D1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTPGKTSLVS LLLLLSLEAI VKAGITIPRN PGCPNSEDKN FPRTVMVNLN IHNRNTNTNP 

        70         80         90        100        110        120 
KRSSDYYNRS TSPWNLHRNE DPERYPSVIW EAKCRHLGCI NADGNVDYHM NSVPIQQEIL 

       130        140        150 
VLRREPPHCP NSFRLEKILV SVGCTCVTPI VHHVA

Q16552 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools