ID   ASTD_PSEA6              Reviewed;         490 AA.
AC   Q15Y60;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-NOV-2008, entry version 24.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase;
DE            Short=SGSD;
GN   Name=astD; OrderedLocusNames=Patl_0649;
OS   Pseudoalteromonas atlantica (strain T6c / BAA-1087).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Pseudoalteromonadaceae; Pseudoalteromonas.
OX   NCBI_TaxID=342610;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Saunders E., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA   Kim E., Karls A.C., Bartlett D., Higgins B.P., Richardson P.;
RT   "Complete sequence of Pseudoalteromonas atlantica T6c.";
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000388; ABG39178.1; -; Genomic_DNA.
DR   RefSeq; YP_660232.1; -.
DR   GeneID; 4173003; -.
DR   GenomeReviews; CP000388_GR; Patl_0649.
DR   KEGG; pat:Patl_0649; -.
DR   NMPDR; fig|342610.3.peg.2924; -.
DR   HOGENOM; Q15Y60; -.
DR   BioCyc; PATL342610:PATL_0649-MON; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:InterPro.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    490       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase.
FT                                /FTId=PRO_0000262411.
FT   NP_BIND     223    228       NAD (By similarity).
FT   ACT_SITE    246    246       By similarity.
FT   ACT_SITE    280    280       By similarity.
SQ   SEQUENCE   490 AA;  53039 MW;  3D98BACBEAE178E6 CRC64;
     MTQQTHFIAG QWHAGQGHDI ESIDPAKKRQ IWQAKSASSE QVNQAVSSAR KATVTWAACT
     FEQRLAYVKR FGELLAENKD MLALTIAQET GKPLWETATE VGAMMGKIGI SERAYQERTG
     LVENPMPVGK AFIRHKPHGV VAVFGPYNFP GHLPNGHIVP ALLAGNCIVF KPSDLTPLVA
     ERTVQLWEKA GLPKGVLNLV QGEVETGKAL AAHPDLDGLF FTGSSRTGKI LHEQYAGHPG
     KILALEMGGN NPLIVKDISD IDATVHDIIQ SAFVTSGQRC TCARKLFLEN NTQGDAILAR
     LIEVTKNIKV GDYDADEQPF MGAMISKNAA HAMVMAQQQL LDLGATSLVE LTHLDPESGF
     VSPGIIDVTA MVEQMPDDEH FGPLLKVVRF DDFDRAISLG NNTKFGLSAG LLSDSEDLYQ
     HFYQRIRAGI VNWNRPITGA SGAAPFGGVG ESGNHRASAY YAADYCAYPV ASVELEKVTL
     PGNLNPGLNF
//