[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7489498 [NCBI, ExPASy, EBI, Israel, Japan]
Kraemer A.,
Mulhauser F.,
Wersig C.,
Groning K.,
Bilbe G.;
"Mammalian splicing factor SF3a120 represents a new member of the SURP family of proteins and is homologous to the essential splicing factor PRP21p of Saccharomyces cerevisiae.";
RNA 1:260-272(1995).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1186/gb-2004-5-10-r84; PubMed=15461802 [NCBI, ExPASy, EBI, Israel, Japan]
Collins J.E.,
Wright C.L.,
Edwards C.A.,
Davis M.P.,
Grinham J.A.,
Cole C.G.,
Goward M.E.,
Aguado B.,
Mallya M.,
Mokrab Y.,
Huckle E.J.,
Beare D.M.,
Dunham I.;
"A genome annotation-driven approach to cloning the human ORFeome.";
Genome Biol. 5:RESEARCH84.1-RESEARCH84.11(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/990031; PubMed=10591208 [NCBI, ExPASy, EBI, Israel, Japan]
Dunham I.,
Hunt A.R.,
Collins J.E.,
Bruskiewich R.,
Beare D.M.,
Clamp M.,
Smink L.J.,
Ainscough R.,
Almeida J.P.,
Babbage A.K.,
Bagguley C.,
Bailey J.,
Barlow K.F.,
Bates K.N.,
Beasley O.P.,
Bird C.P.,
Blakey S.E.,
Bridgeman A.M.,
Buck D., ![]()
Burgess J.,
Burrill W.D.,
Burton J.,
Carder C.,
Carter N.P.,
Chen Y.,
Clark G.,
Clegg S.M.,
Cobley V.E.,
Cole C.G.,
Collier R.E.,
Connor R.,
Conroy D.,
Corby N.R.,
Coville G.J.,
Cox A.V.,
Davis J.,
Dawson E.,
Dhami P.D.,
Dockree C.,
Dodsworth S.J.,
Durbin R.M.,
Ellington A.G.,
Evans K.L.,
Fey J.M.,
Fleming K.,
French L.,
Garner A.A.,
Gilbert J.G.R.,
Goward M.E.,
Grafham D.V.,
Griffiths M.N.D.,
Hall C.,
Hall R.E.,
Hall-Tamlyn G.,
Heathcott R.W.,
Ho S.,
Holmes S.,
Hunt S.E.,
Jones M.C.,
Kershaw J.,
Kimberley A.M.,
King A.,
Laird G.K.,
Langford C.F.,
Leversha M.A.,
Lloyd C.,
Lloyd D.M.,
Martyn I.D.,
Mashreghi-Mohammadi M.,
Matthews L.H.,
Mccann O.T.,
Mcclay J.,
Mclaren S.,
McMurray A.A.,
Milne S.A.,
Mortimore B.J.,
Odell C.N.,
Pavitt R.,
Pearce A.V.,
Pearson D.,
Phillimore B.J.C.T.,
Phillips S.H.,
Plumb R.W.,
Ramsay H.,
Ramsey Y.,
Rogers L.,
Ross M.T.,
Scott C.E.,
Sehra H.K.,
Skuce C.D.,
Smalley S.,
Smith M.L.,
Soderlund C.,
Spragon L.,
Steward C.A.,
Sulston J.E.,
Swann R.M.,
Vaudin M.,
Wall M.,
Wallis J.M.,
Whiteley M.N.,
Willey D.L.,
Williams L.,
Williams S.A.,
Williamson H.,
Wilmer T.E.,
Wilming L.,
Wright C.L.,
Hubbard T.,
Bentley D.R.,
Beck S.,
Rogers J.,
Shimizu N.,
Minoshima S.,
Kawasaki K.,
Sasaki T.,
Asakawa S.,
Kudoh J.,
Shintani A.,
Shibuya K.,
Yoshizaki Y.,
Aoki N.,
Mitsuyama S.,
Roe B.A.,
Chen F.,
Chu L.,
Crabtree J.,
Deschamps S.,
Do A.,
Do T.,
Dorman A.,
Fang F.,
Fu Y.,
Hu P.,
Hua A.,
Kenton S.,
Lai H.,
Lao H.I.,
Lewis J.,
Lewis S.,
Lin S.-P.,
Loh P.,
Malaj E.,
Nguyen T.,
Pan H.,
Phan S.,
Qi S.,
Qian Y.,
Ray L.,
Ren Q.,
Shaull S.,
Sloan D.,
Song L.,
Wang Q.,
Wang Y.,
Wang Z.,
White J.,
Willingham D.,
Wu H.,
Yao Z.,
Zhan M.,
Zhang G.,
Chissoe S.,
Murray J.,
Miller N.,
Minx P.,
Fulton R.,
Johnson D.,
Bemis G.,
Bentley D.,
Bradshaw H.,
Bourne S.,
Cordes M.,
Du Z.,
Fulton L.,
Goela D.,
Graves T.,
Hawkins J.,
Hinds K.,
Kemp K.,
Latreille P.,
Layman D.,
Ozersky P.,
Rohlfing T.,
Scheet P.,
Walker C.,
Wamsley A.,
Wohldmann P.,
Pepin K.,
Nelson J.,
Korf I.,
Bedell J.A.,
Hillier L.W.,
Mardis E.,
Waterston R.,
Wilson R.,
Emanuel B.S.,
Shaikh T.,
Kurahashi H.,
Saitta S.,
Budarf M.L.,
McDermid H.E.,
Johnson A.,
Wong A.C.C.,
Morrow B.E.,
Edelmann L.,
Kim U.J.,
Shizuya H.,
Simon M.I.,
Dumanski J.P.,
Peyrard M.,
Kedra D.,
Seroussi E.,
Fransson I.,
Tapia I.,
Bruder C.E.,
O'Brien K.P.,
Wilkinson P.,
Bodenteich A.,
Hartman K.,
Hu X.,
Khan A.S.,
Lane L.,
Tilahun Y.,
Wright H.;
"The DNA sequence of human chromosome 22.";
Nature 402:489-495(1999).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix, and Lymph;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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CHARACTERIZATION OF THE SPLICEOSOME.
DOI=10.1016/S1097-2765(00)80318-4; PubMed=10882114 [NCBI, ExPASy, EBI, Israel, Japan]
Das R.,
Zhou Z.,
Reed R.;
"Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.";
Mol. Cell 5:779-787(2000).
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[6]
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IDENTIFICATION BY MASS SPECTROMETRY, AND IDENTIFICATION IN THE SPICEOSOMAL C COMPLEX.
DOI=10.1017/S1355838202021088; PubMed=11991638 [NCBI, ExPASy, EBI, Israel, Japan]
Jurica M.S.,
Licklider L.J.,
Gygi S.P.,
Grigorieff N.,
Moore M.J.;
"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.";
RNA 8:426-439(2002).
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[7]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-359, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1073/pnas.0404720101; PubMed=15302935 [NCBI, ExPASy, EBI, Israel, Japan]
Beausoleil S.A.,
Jedrychowski M.,
Schwartz D.,
Elias J.E.,
Villen J.,
Li J.,
Cohn M.A.,
Cantley L.C.,
Gygi S.P.;
"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
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[8]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-456 AND TYR-759, AND MASS SPECTROMETRY.
DOI=10.1038/nbt1046; PubMed=15592455 [NCBI, ExPASy, EBI, Israel, Japan]
Rush J.,
Moritz A.,
Lee K.A.,
Guo A.,
Goss V.L.,
Spek E.J.,
Zhang H.,
Zha X.-M.,
Polakiewicz R.D.,
Comb M.J.;
"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.";
Nat. Biotechnol. 23:94-101(2005).
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[9]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329 AND SER-359, AND MASS SPECTROMETRY.
TISSUE=Epithelium;
DOI=10.1016/j.cell.2006.09.026; PubMed=17081983 [NCBI, ExPASy, EBI, Israel, Japan]
Olsen J.V.,
Blagoev B.,
Gnad F.,
Macek B.,
Kumar C.,
Mortensen P.,
Mann M.;
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.";
Cell 127:635-648(2006).
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[10]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-320; SER-329 AND SER-359, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0611217104; PubMed=17287340 [NCBI, ExPASy, EBI, Israel, Japan]
Molina H.,
Horn D.M.,
Tang N.,
Mathivanan S.,
Pandey A.;
"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry.";
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
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[11]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-124, AND MASS SPECTROMETRY.
DOI=10.1126/science.1140321; PubMed=17525332 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuoka S.,
Ballif B.A.,
Smogorzewska A.,
McDonald E.R. III,
Hurov K.E.,
Luo J.,
Bakalarski C.E.,
Zhao Z.,
Solimini N.,
Lerenthal Y.,
Shiloh Y.,
Gygi S.P.,
Elledge S.J.;
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.";
Science 316:1160-1166(2007).
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[12]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329; SER-413 AND SER-451, AND MASS SPECTROMETRY.
DOI=10.1073/pnas.0805139105; PubMed=18669648 [NCBI, ExPASy, EBI, Israel, Japan]
Dephoure N.,
Zhou C.,
Villen J.,
Beausoleil S.A.,
Bakalarski C.E.,
Elledge S.J.,
Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
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[13]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-329, AND MASS SPECTROMETRY.
TISSUE=Liver;
DOI=10.1002/pmic.200700884; PubMed=18318008 [NCBI, ExPASy, EBI, Israel, Japan]
Han G.,
Ye M.,
Zhou H.,
Jiang X.,
Feng S.,
Jiang X.,
Tian R.,
Wan D.,
Zou H.,
Gu J.;
"Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.";
Proteomics 8:1346-1361(2008).
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[14]
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STRUCTURE BY NMR OF 704-789.
Structural genomics consortium (SGC);
"Solution structure of a human ubiquitin-like domain in SF3A1.";
Submitted (JUN-2005) to the PDB data bank.
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[15]
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VARIANT [LARGE SCALE ANALYSIS] TRP-511.
DOI=10.1126/science.1133427; PubMed=16959974 [NCBI, ExPASy, EBI, Israel, Japan]
Sjoeblom T.,
Jones S.,
Wood L.D.,
Parsons D.W.,
Lin J.,
Barber T.D.,
Mandelker D.,
Leary R.J.,
Ptak J.,
Silliman N.,
Szabo S.,
Buckhaults P.,
Farrell C.,
Meeh P.,
Markowitz S.D.,
Willis J.,
Dawson D.,
Willson J.K.V.,
Gazdar A.F., ![]()
Hartigan J.,
Wu L.,
Liu C.,
Parmigiani G.,
Park B.H.,
Bachman K.E.,
Papadopoulos N.,
Vogelstein B.,
Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
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- FUNCTION: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
- SUBUNIT: Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A3.
- INTERACTION:
O94817:ATG12; NbExp=1; IntAct=EBI-1054743, EBI-746742;
P08047:SP1; NbExp=1; IntAct=EBI-1054743, EBI-298336;
- SUBCELLULAR LOCATION: Nucleus (By similarity).
- TISSUE SPECIFICITY: Ubiquitously expressed.
- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
- SIMILARITY: Contains 2 SURP motif repeats.
- SIMILARITY: Contains 1 ubiquitin-like domain.
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