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UniProtKB/Swiss-Prot entry Q14457


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BECN1_HUMAN
Primary accession number Q14457
Secondary accession numbers O75595 Q9UNA8
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on February 21, 2001 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 75)
Name and origin of the protein
Protein name Beclin-1
Synonyms Coiled-coil myosin-like BCL2-interacting protein
Protein GT197
Gene name
Name: BECN1
Synonyms: GT197
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH BCL-2.
TISSUE=Brain;
PubMed=9765397 [NCBI, ExPASy, EBI, Israel, Japan]
Liang X.H., Kleeman L.K., Jiang H.H., Gordon G., Goldman J.E., Berry G., Herman B., Levine B.;
"Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein.";
J. Virol. 72:8586-8596(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1999.5851; PubMed=10395800 [NCBI, ExPASy, EBI, Israel, Japan]
Aita V.M., Liang X.H., Murty V.V.V.S., Pincus D.L., Yu W., Cayanis E., Kalachikov S., Gilliam T.C., Levine B.;
"Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21.";
Genomics 59:59-65(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cervix;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 150-450.
TISSUE=Mammary gland;
DOI=10.1006/geno.1995.1185; PubMed=7490091 [NCBI, ExPASy, EBI, Israel, Japan]
Rommens J.M., Durocher F., McArthur J., Tonin P., Leblanc J.-F., Allen T., Samson C., Ferri L., Narod S., Morgan K., Simard J.;
"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21.";
Genomics 28:530-542(1995).
[5]
X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 107-135 IN COMPLEX WITH BCL2L1.
DOI=10.1074/jbc.M700492200; PubMed=17337444 [NCBI, ExPASy, EBI, Israel, Japan]
Oberstein A., Jeffrey P.D., Shi Y.;
"Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein.";
J. Biol. Chem. 282:13123-13132(2007).
[6]
STRUCTURE BY NMR OF 106-128 IN COMPLEX WITH BCL2L1.
DOI=10.1016/j.jmb.2007.06.069; PubMed=17659302 [NCBI, ExPASy, EBI, Israel, Japan]
Feng W., Huang S., Wu H., Zhang M.;
"Molecular basis of Bcl-xL's target recognition versatility revealed by the structure of Bcl-xL in complex with the BH3 domain of beclin-1.";
J. Mol. Biol. 372:223-235(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF077301; AAC68653.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF139131; AAD27650.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC010276; AAH10276.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L38932; AAB59573.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I54209; I54209.
RefSeq NP_003757.1; -.
UniGene Hs.12272
3D structure databases
PDB
2P1L; X-ray; 2.50 A; B/D/F/H=107-135.[ExPASy / RCSB / EBI]
2PON; NMR; -; A=106-128.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 2P1L; -.
2PON; -.
ModBase Q14457.
Organism-specific databases
H-InvDB HIX0018211; -.
HGNC HGNC:1034; BECN1.
GenAtlas BECN1.
HPA CAB010143; -.
MIM 604378; gene. [NCBI / EBI]
PharmGKB PA25337; -.
GeneCards Q14457.
Gene expression databases
ArrayExpress Q14457; -.
CleanEx HS_BECN1; -.
GermOnline ENSG00000126581; Homo sapiens.
Ontologies
GO
GO:0006916; Biological process: anti-apoptosis (traceable author statement from ProtInc).
GO:0006968; Biological process: cellular defense response (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR007243; Autophagy_prot_6.
Graphical view of domain structure.
PANTHER PTHR12768; APG6; 1.
Pfam PF04111; APG6; 1.
Pfam graphical view of domain structure.
BLOCKS Q14457.
Genome annotation databases
Ensembl ENSG00000126581; Homo sapiens. [Contig view]
GeneID 8678; -.
KEGG hsa:8678; -.
Phylogenomic databases
HOVERGEN Q14457; -.
Other
LinkHub Q14457; -.
SOURCE BECN1; Homo sapiens.
ProtoNet Q14457.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Antiviral defense; Autophagy; Coiled coil; Cytoplasm; Golgi apparatus; Membrane; Polymorphism.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   450  450     Beclin-1. PRO_0000218555
COILED   142   270  129     Potential. 
VARIANT   103   103  1     A -> V. VAR_010384 
VARIANT   403   403  1     I -> T. VAR_005236 
CONFLICT   150   150        T -> A (in Ref. 4; AAB59573). 
HELIX   107   125  19      
Sequence information
Length: 450 AA [This is the length of the unprocessed precursor] Molecular weight: 51896 Da [This is the MW of the unprocessed precursor] CRC64: ABF0C2DD7087473C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE 

        70         80         90        100        110        120 
ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG 

       130        140        150        160        170        180 
DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL 

       190        200        210        220        230        240 
QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ 

       250        260        270        280        290        300 
LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW 

       310        320        330        340        350        360 
NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF 

       370        380        390        400        410        420 
WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN 

       430        440        450 
SEEQWTKALK FMLTNLKWGL AWVSSQFYNK 

Q14457 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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