ID   MHPF_BURXL              Reviewed;         313 AA.
AC   Q13QH7;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-NOV-2008, entry version 22.
DE   RecName: Full=Acetaldehyde dehydrogenase;
DE            EC=1.2.1.10;
DE   AltName: Full=Acetaldehyde dehydrogenase [acetylating];
GN   Name=mhpF; OrderedLocusNames=Bxeno_B0694; ORFNames=Bxe_B2326;
OS   Burkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- FUNCTION: Catalyzes the terminal reaction in meta-cleavage
CC       pathways, that is, the transformation of acetaldehyde into acetyl
CC       coenzyme A (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetaldehyde + CoA + NAD(+) = acetyl-CoA +
CC       NADH.
CC   -!- PATHWAY: Aromatic compound metabolism; 3-phenylpropionic acid
CC       degradation.
CC   -!- SIMILARITY: Belongs to the acetaldehyde dehydrogenase family. MhpF
CC       subfamily.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000271; ABE33662.1; -; Genomic_DNA.
DR   RefSeq; YP_553012.1; -.
DR   SMR; Q13QH7; 3-313.
DR   GeneID; 4007178; -.
DR   GenomeReviews; CP000271_GR; Bxeno_B0694.
DR   KEGG; bxe:Bxe_B2326; -.
DR   HOGENOM; Q13QH7; -.
DR   BioCyc; BXEN266265:BXE_B2326-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) ac...; IEA:HAMAP.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01657; -; 1.
DR   InterPro; IPR003361; Acetylald_dehydrogenase.
DR   InterPro; IPR015426; Acetylald_DHase_C.
DR   InterPro; IPR000534; Semialdehyde_DHase_NAD-bd.
DR   InterPro; IPR006035; Ureohydrolase.
DR   PANTHER; PTHR21123; Acetylald_dh; 1.
DR   Pfam; PF09290; AcetDehyd-dimer; 1.
DR   Pfam; PF01118; Semialdhyde_dh; 1.
DR   PIRSF; PIRSF015689; Actaldh_dh_actl; 1.
DR   TIGRFAMs; TIGR03215; ac_ald_DH_ac; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Complete proteome; NAD;
KW   Oxidoreductase.
FT   CHAIN         1    313       Acetaldehyde dehydrogenase.
FT                                /FTId=PRO_0000337977.
SQ   SEQUENCE   313 AA;  32763 MW;  F0A85325E5E6BAD5 CRC64;
     MASEKLKAAI IGSGNIGTDL MIKIMRHSEH LEMAAMVGID AASDGLARAA RLGVATTHEG
     VEGLTRLPVF DDIDFVFDAT SAGAHVKNDA FLRALKPGIR LIDLTPAAIG PYCVPVVNLD
     AHLDSRNVNM VTCGGQATIP MVAAVSRVAK VHYAEIVASI SSKSAGPGTR ANIDEFTETT
     SKAIEAVGGA AKGKAIIVLN PAEPPVMMRD TVYVLSDLAD RAQVEASIEA MAAAVHAYVP
     GYRLKQKVQF DEIAADVPLN IPGLGRFSGL KTSVFIEVEG AAHYLPAYAG NLDIMTSAAL
     ATAERMAQSL VQA
//