ID   BETB_BURXL              Reviewed;         489 AA.
AC   Q13NG6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   04-NOV-2008, entry version 18.
DE   RecName: Full=Betaine aldehyde dehydrogenase;
DE            Short=BADH;
DE            EC=1.2.1.8;
GN   Name=betB; OrderedLocusNames=Bxeno_B1405; ORFNames=Bxe_B1591;
OS   Burkholderia xenovorans (strain LB400).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia.
OX   NCBI_TaxID=266265;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17030797; DOI=10.1073/pnas.0606924103;
RA   Chain P.S.G., Denef V.J., Konstantinidis K.T., Vergez L.M., Agullo L.,
RA   Reyes V.L., Hauser L., Cordova M., Gomez L., Gonzalez M., Land M.,
RA   Lao V., Larimer F., LiPuma J.J., Mahenthiralingam E., Malfatti S.A.,
RA   Marx C.J., Parnell J.J., Ramette A., Richardson P., Seeger M.,
RA   Smith D., Spilker T., Sul W.J., Tsoi T.V., Ulrich L.E., Zhulin I.B.,
RA   Tiedje J.M.;
RT   "Burkholderia xenovorans LB400 harbors a multi-replicon, 9.73-Mbp
RT   genome shaped for versatility.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15280-15287(2006).
CC   -!- CATALYTIC ACTIVITY: Betaine aldehyde + NAD(+) + H(2)O = betaine +
CC       NADH.
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine from betaine aldehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; CP000271; ABE34373.1; -; Genomic_DNA.
DR   RefSeq; YP_553723.1; -.
DR   GeneID; 4007920; -.
DR   GenomeReviews; CP000271_GR; Bxeno_B1405.
DR   KEGG; bxe:Bxe_B1591; -.
DR   HOGENOM; Q13NG6; -.
DR   BioCyc; BXEN266265:BXE_B1591-MON; -.
DR   GO; GO:0008802; F:betaine-aldehyde dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00804; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR011264; Betaine_Ald_DHase.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   TIGRFAMs; TIGR01804; BADH; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    489       Betaine aldehyde dehydrogenase.
FT                                /FTId=PRO_1000047042.
FT   NP_BIND     228    233       NAD (By similarity).
FT   ACT_SITE    251    251       By similarity.
FT   ACT_SITE    285    285       By similarity.
SQ   SEQUENCE   489 AA;  52414 MW;  01A05941F3834FFC CRC64;
     MAVFAIQRLY IGGAYVDATS GETFDTLDPA TGETLASVQQ ASAADVERAV QSAREGQREW
     AALTAMQRSR VLRRAVEILR ERNDELAALE TRDTGKPIAE TLAVDIATGA DVIEYYAGLA
     TAIEGQQIPL RPTSFVYTRR EPLGVCAGIG AWNYPIQIAC WKSAPALAAG NAMIFKPSEI
     TPLSALKLAE IYTEAGVPAG VFNVVQGDGR VGAMLAAHPD IEKISFTGGV ETGKKVMSLA
     GASSLKEVTM ELGGKSPLLV FDDADLERAA DIAMSANFFS SGQVCTNGTR VFVQRGVLER
     FEALVLERVK RIRVGAPTNA ATNFGPLASA AQLQKVLGYI ESGKQEGARL MAGGKRLTEG
     HFGNGQYVEP TVFTGCHDDM RIVREEIFGP VMSILVFDDE DEAIARANRT AYGLAAGVVT
     GNLARAHRVI HRLEAGICWI NTWGESPAEM PVGGYKQSGV GRENGLTTLE HYTRIKSVQV
     ELGPYQPVF
//