ID   HGD_RHOPS               Reviewed;         448 AA.
AC   Q13CD3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   04-NOV-2008, entry version 15.
DE   RecName: Full=Homogentisate 1,2-dioxygenase;
DE            EC=1.13.11.5;
DE   AltName: Full=Homogentisicase;
DE   AltName: Full=Homogentisate oxygenase;
DE   AltName: Full=Homogentisic acid oxidase;
GN   Name=hmgA; OrderedLocusNames=RPD_1018;
OS   Rhodopseudomonas palustris (strain BisB5).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Bradyrhizobiaceae; Rhodopseudomonas.
OX   NCBI_TaxID=316057;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Pelletier D.A., Kyrpides N.,
RA   Lykidis A., Oda Y., Harwood C.S., Richardson P.;
RT   "Complete sequence of Rhodopseudomonas palustris BisB5.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: Homogentisate + O(2) = 4-maleylacetoacetate.
CC   -!- COFACTOR: Iron (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-phenylalanine degradation;
CC       acetoacetic acid and fumarate from L-phenylalanine: step 4/6.
CC   -!- SIMILARITY: Belongs to the homogentisate dioxygenase family.
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DR   EMBL; CP000283; ABE38256.1; -; Genomic_DNA.
DR   RefSeq; YP_568157.1; -.
DR   GeneID; 4021493; -.
DR   GenomeReviews; CP000283_GR; RPD_1018.
DR   KEGG; rpd:RPD_1018; -.
DR   HOGENOM; Q13CD3; -.
DR   BioCyc; RPAL316057:RPD_1018-MON; -.
DR   GO; GO:0004411; F:homogentisate 1,2-dioxygenase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:HAMAP.
DR   GO; GO:0006559; P:L-phenylalanine catabolic process; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006572; P:tyrosine catabolic process; IEA:HAMAP.
DR   HAMAP; MF_00334; -; 1.
DR   InterPro; IPR005708; Homogentis_dOase.
DR   PANTHER; PTHR11056; Homogentis_dOase; 1.
DR   Pfam; PF04209; HgmA; 1.
DR   TIGRFAMs; TIGR01015; hmgA; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase;
KW   Phenylalanine catabolism; Tyrosine catabolism.
FT   CHAIN         1    448       Homogentisate 1,2-dioxygenase.
FT                                /FTId=PRO_1000019543.
FT   METAL       346    346       Iron (By similarity).
FT   METAL       352    352       Iron (By similarity).
FT   METAL       382    382       Iron (By similarity).
SQ   SEQUENCE   448 AA;  49546 MW;  2DAF089317B04E5C CRC64;
     MNVNAAPEIV GRASQGVTPG YMSGFGNSFE TEALPGALPV GRNSPQRAAY GLYAEQLSGS
     PFTAPRGANE RSWLYRIRPS VKHSGRFAKA DMGLWRSAPC LEHDMPIAQL RWDAPPMPTE
     EVTFVQGVRT MTTAGDVNTQ AGMAAHMYLI SRSMVDQHFY NADGELMFVP QQGRLRLVTE
     FGVIAIEPAE IAVIPRGVKF RVELVDGPAR GYLCENYGGA FTLPERGPIG ANCLANSRDF
     LTPVASYEDK DTPTELFVKW GGALWRTSLP HSPIDVVAWH GNYAPYKYDL RTFSPVGAIG
     FDHPDPSIFT VLTSPSETAG TANIDFVIFP ERWMVAENTF RPPWYHMNIM SEFMGLIYGV
     YDAKPQGFAP GGASLHNMML PHGPDREAFD HASNGELKPV KLTGTMAFML ETRYPQRVTE
     YAATADTLQD DYADCWRGLE KRFDPSRP
//