ID   ASTD2_SHEDO             Reviewed;         486 AA.
AC   Q12JA9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   25-NOV-2008, entry version 24.
DE   RecName: Full=N-succinylglutamate 5-semialdehyde dehydrogenase 2;
DE            EC=1.2.1.71;
DE   AltName: Full=Succinylglutamic semialdehyde dehydrogenase 2;
DE            Short=SGSD 2;
GN   Name=astD2; OrderedLocusNames=Sden_3191;
OS   Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Alteromonadales;
OC   Shewanellaceae; Shewanella.
OX   NCBI_TaxID=318161;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H.,
RA   Pitluck S., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Kiss H.,
RA   Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA   Richardson P.;
RT   "Complete sequence of Shewanella denitrificans OS217.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the NAD-dependent reduction of
CC       succinylglutamate semialdehyde into succinylglutamate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD(+)
CC       + H(2)O = N-succinyl-L-glutamate + NADH.
CC   -!- PATHWAY: Amino-acid degradation; L-arginine degradation via AST
CC       pathway; L-glutamate and succinate from L-arginine: step 4/5.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD
CC       subfamily.
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DR   EMBL; CP000302; ABE56467.1; -; Genomic_DNA.
DR   RefSeq; YP_564190.1; -.
DR   GeneID; 4019717; -.
DR   GenomeReviews; CP000302_GR; Sden_3191.
DR   KEGG; sdn:Sden_3191; -.
DR   NMPDR; fig|318161.14.peg.3098; -.
DR   HOGENOM; Q12JA9; -.
DR   BioCyc; SDEN318161:SDEN_3191-MON; -.
DR   GO; GO:0043824; F:succinylglutamate-semialdehyde dehydrogenas...; IEA:InterPro.
DR   GO; GO:0019544; P:arginine catabolic process to glutamate; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01174; -; 1.
DR   InterPro; IPR016160; Ald_DHase_CS.
DR   InterPro; IPR016162; Ald_DHase_N.
DR   InterPro; IPR015590; Aldehyde_DHase.
DR   InterPro; IPR017649; SuccinylGlu_semiald_DH_AstD.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE   3: Inferred from homology;
KW   Arginine metabolism; Complete proteome; NAD; Oxidoreductase.
FT   CHAIN         1    486       N-succinylglutamate 5-semialdehyde
FT                                dehydrogenase 2.
FT                                /FTId=PRO_0000262424.
FT   NP_BIND     220    225       NAD (By similarity).
FT   ACT_SITE    243    243       By similarity.
FT   ACT_SITE    277    277       By similarity.
SQ   SEQUENCE   486 AA;  51409 MW;  989D044D58AFB4C0 CRC64;
     MTQYINGQWF AGLGHQVSSI NPATGQSIWN GVTATADQVN QAVDAARAAQ FDWFMLGFEA
     RLSIVEAYRS ELEANKAQLA EVIAQETGKP QWETATEVGA MIGKIALSAA AHDKRTGTET
     NELAAGRAVL RHKPHGVVAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS ELTPKVAEEM
     LKLWDKAGLP KGVINLVQGE VETGKALASH PQIDGLFFTG SSRTGHILHQ QYAGHPGKIL
     ALEMGGNNPL IVKGVSDTKA AVHDIIQSAY ISSGQRCTCA RRLYIEQGAA GDELIAQLIT
     AVNNIQVGAW NSQPQPFMGS MISETAARGM VAAQATLQAL GGVSLVELAQ VEAGTGLVSP
     GLIDVTQIAE LPDEEYFGPL LQLVRYTDFD EAIRLANATR YGLSAGLLAD NRDDYDYFLA
     RIRAGIVNWN KQITGASGAA PFGGVGASGN HRASAFYAAD YCAYPVASME ADSVSMPASL
     SPGLSI
//