ID   P5CR_ZALAR              Reviewed;         320 AA.
AC   Q12740;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-NOV-2008, entry version 44.
DE   RecName: Full=Pyrroline-5-carboxylate reductase;
DE            Short=P5C reductase;
DE            Short=P5CR;
DE            EC=1.5.1.2;
GN   Name=P5CR;
OS   Zalerion arboricola.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; mitosporic Ascomycota;
OC   Zalerion.
OX   NCBI_TaxID=42465;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 20868 / MF5171;
RX   MEDLINE=96257270; PubMed=8654976; DOI=10.1016/0378-1119(96)00107-2;
RA   Kelly R., Register E.;
RT   "Isolation and sequence analysis of the cDNA encoding delta 1-
RT   pyrroline-5-carboxylate reductase from Zalerion arboricola.";
RL   Gene 172:149-153(1996).
CC   -!- CATALYTIC ACTIVITY: L-proline + NAD(P)(+) = 1-pyrroline-5-
CC       carboxylate + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-
CC       proline from L-glutamate 5-semialdehyde: step 1/1.
CC   -!- SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase
CC       family.
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DR   EMBL; U33266; AAC49320.1; -; mRNA.
DR   PIR; JC4830; JC4830.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0004735; F:pyrroline-5-carboxylate reductase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006561; P:proline biosynthetic process; IEA:InterPro.
DR   InterPro; IPR004455; NADP_OxRdtase_F420.
DR   InterPro; IPR000304; P5CR.
DR   PANTHER; PTHR11645; P5CR; 1.
DR   Pfam; PF03807; F420_oxidored; 1.
DR   PIRSF; PIRSF000193; Pyrrol-5-carb_rd; 1.
DR   TIGRFAMs; TIGR00112; proC; 1.
DR   PROSITE; PS00521; P5CR; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; NADP; Oxidoreductase; Proline biosynthesis.
FT   CHAIN         1    320       Pyrroline-5-carboxylate reductase.
FT                                /FTId=PRO_0000187329.
SQ   SEQUENCE   320 AA;  32975 MW;  90F0ADC59F0AE7F2 CRC64;
     MASTAKEGSE LTLAVIGCGT MGIAILSGIL ASLDEIHAPN SQSSETDETP SKLPTKFIAC
     VRSPKGAEKI KKALSPYKTP VKIIQSDNVT ACREADVVLL GCKPYMAEGI LGEEGMVDAL
     KGKLLISILA GVPAEQIYGY MYGKTPVNPE KEGLCQVVRA MPNTASGIRE SMTVIATSSP
     PLSATTSSLI TWIFKRIGDV VQLPAATMDA STALCGSGPA FFALILEAAI DGAVAMGLPR
     AEAQRMAAQT MKGAAGLVLS GEHPALLKDK VTTPGGCTIG GLMVLEEGGV RGTVARAVRE
     ATVVASQLGK GVQGVNGTRF
//