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UniProtKB/Swiss-Prot entry Q12718

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LAC2_TRAVE
Primary accession number Q12718
Secondary accession number Q12716
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 59)
Name and origin of the protein
Protein name Laccase-2 [Precursor]
Synonyms EC 1.10.3.2
Benzenediol:oxygen oxidoreductase 2
Urishiol oxidase 2
Diphenol oxidase 2
Laccase I
Gene name
Name: LCC2
Synonyms: LCCI
From
Trametes versicolor (White-rot fungus) (Coriolus versicolor) [TaxID: 5325] 
Taxonomy Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; Polyporales; Trametes.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=ATCC 20869 / PAP 52 / 52J;
DOI=10.1016/S0378-1119(97)00215-1; PubMed=9322748 [NCBI, ExPASy, EBI, Israel, Japan]
Ong E., Pollock W.B., Smith M.;
"Cloning and sequence analysis of two laccase complementary DNAs from the ligninolytic basidiomycete Trametes versicolor.";
Gene 196:113-119(1997).
[2]
 X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS).
DOI=10.1074/jbc.M204571200; PubMed=12163489 [NCBI, ExPASy, EBI, Israel, Japan]
Piontek K., Antorini M., Choinowski T.;
"Crystal structure of a laccase from the fungus Trametes versicolor at 1.90-A resolution containing a full complement of coppers.";
J. Biol. Chem. 277:37663-37669(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U44851; AAA86659.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U44430; AAC49828.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
PDB
1GYC; X-ray; 1.90 A; A=21-519.[ExPASy / RCSB / EBI]
PDBsum 1GYC; -.
ModBase Q12718.
Family and domain databases
InterPro IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.420; Cupredoxin; 3.
Pfam PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.
PROSITE PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; FALSE_NEG.
BLOCKS Q12718.
Other
ProtoNet Q12718.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   519  499     Laccase-2. PRO_0000002940
DOMAIN   22   147  126     Plastocyanin-like 1. 
DOMAIN   159   301  143     Plastocyanin-like 2. 
DOMAIN   368   490  123     Plastocyanin-like 3. 
METAL   84    84        Copper 1; type 2. 
METAL   86    86        Copper 2; type 3. 
METAL   129   129        Copper 2; type 3. 
METAL   131   131        Copper 3; type 3. 
METAL   415   415        Copper 4; type 1. 
METAL   418   418        Copper 1; type 2. 
METAL   420   420        Copper 3; type 3. 
METAL   472   472        Copper 3; type 3. 
METAL   473   473        Copper 4; type 1. 
METAL   474   474        Copper 2; type 3. 
METAL   478   478        Copper 4; type 1. 
CARBOHYD   74    74        N-linked (GlcNAc...). 
CARBOHYD   161   161        N-linked (GlcNAc...) (Potential). 
CARBOHYD   228   228        N-linked (GlcNAc...) (Potential). 
CARBOHYD   237   237        N-linked (GlcNAc...). 
CARBOHYD   271   271        N-linked (GlcNAc...). 
CARBOHYD   353   353        N-linked (GlcNAc...). 
CARBOHYD   361   361        N-linked (GlcNAc...). 
CARBOHYD   456   456        N-linked (GlcNAc...). 
CONFLICT   69    69        D -> V (in Ref. 1; AAC49828). 
STRAND   24    35  12      
STRAND   42    47  6      
STRAND   50    52  3      
STRAND   56    59  4      
STRAND   63    70  8      
HELIX   75    77  3      
STRAND   83    86  4      
HELIX   94    96  3      
TURN   100   102  3      
STRAND   111   118  8      
STRAND   124   130  7      
HELIX   135   138  4      
STRAND   141   147  7      
HELIX   154   156  3      
HELIX   162   164  3      
STRAND   165   171  7      
TURN   176   178  3      
STRAND   187   191  5      
STRAND   207   210  4      
STRAND   215   222  8      
STRAND   229   233  5      
STRAND   238   243  6      
STRAND   246   258  13      
STRAND   263   269  7      
STRAND   274   287  14      
HELIX   291   293  3      
STRAND   296   301  6      
STRAND   317   319  3      
HELIX   322   324  3      
STRAND   327   329  3      
STRAND   342   347  6      
STRAND   350   352  3      
STRAND   357   359  3      
HELIX   371   376  6      
TURN   382   384  3      
STRAND   385   387  3      
STRAND   390   394  5      
STRAND   399   405  7      
STRAND   416   419  4      
STRAND   424   428  5      
STRAND   437   439  3      
STRAND   442   447  6      
HELIX   451   453  3      
STRAND   456   462  7      
STRAND   467   475  9      
HELIX   476   480  5      
STRAND   484   489  6      
HELIX   491   493  3      
HELIX   494   497  4      
HELIX   502   512  11      
HELIX   516   518  3      
Sequence information
Length: 519 AA [This is the length of the unprocessed precursor] Molecular weight: 55811 Da [This is the MW of the unprocessed precursor] CRC64: BFFB5B4CD0007702 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGLQRFSFFV TLALVARSLA AIGPVASLVV ANAPVSPDGF LRDAIVVNGV VPSPLITGKK 

        70         80         90        100        110        120 
GDRFQLNVDD TLTNHSMLKS TSIHWHGFFQ AGTNWADGPA FVNQCPIASG HSFLYDFHVP 

       130        140        150        160        170        180 
DQAGTFWYHS HLSTQYCDGL RGPFVVYDPK DPHASRYDVD NESTVITLTD WYHTAARLGP 

       190        200        210        220        230        240 
RFPLGADATL INGLGRSAST PTAALAVINV QHGKRYRFRL VSISCDPNYT FSIDGHNLTV 

       250        260        270        280        290        300 
IEVDGINSQP LLVDSIQIFA AQRYSFVLNA NQTVGNYWVR ANPNFGTVGF AGGINSAILR 

       310        320        330        340        350        360 
YQGAPVAEPT TTQTTSVIPL IETNLHPLAR MPVPGSPTPG GVDKALNLAF NFNGTNFFIN 

       370        380        390        400        410        420 
NATFTPPTVP VLLQILSGAQ TAQDLLPAGS VYPLPAHSTI EITLPATALA PGAPHPFHLH 

       430        440        450        460        470        480 
GHAFAVVRSA GSTTYNYNDP IFRDVVSTGT PAAGDNVTIR FQTDNPGPWF LHCHIDFHLD 

       490        500        510 
AGFAIVFAED VADVKAANPV PKAWSDLCPI YDGLSEANQ
Q12718 in FASTA format

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