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UniProtKB/Swiss-Prot entry Q12649

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_PHYBL
Primary accession number Q12649
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on August 29, 2001 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name
Name: hmgA
From
Phycomyces blakesleeanus [TaxID: 4837] 
Taxonomy Eukaryota; Fungi; Fungi incertae sedis; Basal fungal lineages; Mucoromycotina; Mucorales; Mucoraceae; Phycomyces.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=NRRL 1555;
Ruiz-Albert J., Cerda-Olmedo E., Corrochano L.M.;
"Genes for the metabolism of 3-hydroxy-3-methylglutaryl coenzyme A in the fungus Phycomyces.";
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 836-940.
STRAIN=NRRL 1555;
Corrochano L.M., Avalos J.;
"Cloning a segment of the gene encoding 3-hydroxy-3-methyglutaryl coenzyme A reductase in Phycomyces blakesleeanus and Gibberella fujikuroi.";
Exp. Mycol. 16:167-171(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X58371; CAB97179.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S17345; S17345.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase Q12649.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
IPR000731; SSD_5TM.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PS50156; SSD; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q12649.
Other
ProtoNet Q12649.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Endoplasmic reticulum; Glycoprotein; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1176  1176     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114453
TRANSMEM   35     55  21     Potential. 
TRANSMEM   300    320  21     Potential. 
TRANSMEM   331    351  21     Potential. 
TRANSMEM   623    643  21     Potential. 
REGION   647    744  98     Linker (By similarity). 
REGION   745   1176  432     Catalytic (By similarity). 
ACT_SITE   841    841        Charge relay system (By similarity). 
ACT_SITE   972    972        Charge relay system (By similarity). 
ACT_SITE   1048   1048        Charge relay system (By similarity). 
ACT_SITE   1146   1146        Proton donor (By similarity). 
CARBOHYD   224    224        N-linked (GlcNAc...) (Potential). 
CARBOHYD   238    238        N-linked (GlcNAc...) (Potential). 
CARBOHYD   553    553        N-linked (GlcNAc...) (Potential). 
CARBOHYD   596    596        N-linked (GlcNAc...) (Potential). 
CARBOHYD   670    670        N-linked (GlcNAc...) (Potential). 
CARBOHYD   904    904        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1013   1013        N-linked (GlcNAc...) (Potential). 
CARBOHYD   1066   1066        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 1176 AA [This is the length of the unprocessed precursor] Molecular weight: 127819 Da [This is the MW of the unprocessed precursor] CRC64: 6BA5C23E828DF35F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLPNHSGSS AFKSFSYIVG TGIKRAAKLS TRNPIEMIVV VLILSSFSYF YLFNLARTSD 

        70         80         90        100        110        120 
IFSGTVTRLY PTSVYAPTKD HSFSVVDRTA DSTIANNAVK VHLHQIVVSD PKHGVLSRQT 

       130        140        150        160        170        180 
LASVLRFQQM AENEIYVPDS TAVNRFAFNK DLCYKTTLPS SYSSHSSDSN SNSNLNSKTS 

       190        200        210        220        230        240 
PCFAHSPADI WQDEATLLAD KNIRSTIEAN LDTAKNVFGD LQLNATYASS VTLSYAFNTT 

       250        260        270        280        290        300 
GDYREHLADM WKHKVATLPP ADLVSLSNIG QQENVFAWLF IVTRNVIFRV KELIDLADNI 

       310        320        330        340        350        360 
DIIVILVGYI MMIATFISLY VNMRAMGSRY TLATAVVFNG FFSFMLALLT VRALGVDVYP 

       370        380        390        400        410        420 
VVLAEAIPFL AVTIGFERPF KLTKRVFQFS KETPLTKQEI RTTIMRAVDT VALPIARDCF 

       430        440        450        460        470        480 
MEIIVLVLGA KSGISGLEEF CLLSAILLAY DFIIMFTWYT AVLALKLELL RIREINGISA 

       490        500        510        520        530        540 
DDIKKGTKKS TGYIRRTVIK AFSDDHAAGA NTANQKADGP IIGRVKLLMI VGFVVMHIFK 

       550        560        570        580        590        600 
FCSAFQSVGP QVNITEPSIA VVLDQLLEQH KASSQASLPL FVQVFPAMPF HVATVNKSFV 

       610        620        630        640        650        660 
PDAITRPLEA LFDTYAVYIQ HPVISKWLTI ALFVSLFLNT YLFNVAKQPK QIVEQVNQDK 

       670        680        690        700        710        720 
KITNAIESTN NTHIEVTEKQ KPTIQSPGPV VSSAVVMSPN HKRSHNHHHS HSHSHNHHSN 

       730        740        750        760        770        780 
HHQSDIVRPI DECVALVRTP EMLNDEEVIS LVENGKMASY ALEKVLGDLQ RAVGIRRALI 

       790        800        810        820        830        840 
SRASITKTLE ASALPLENYH YDKVMGACCE NVIGYMPIPV GVAGPMNIDG DLIHIPMATT 

       850        860        870        880        890        900 
EGCLVASTAR GCKAINAGGG ASTIVIADGM TRGPCVEFPT ILRAAACKLW IENEGNDIVT 

       910        920        930        940        950        960 
NAFNSTSRFA RLRKLKIALA GKLVFIRFST TTGDAMGMNM ISKGCEKALS IITEHFPDMQ 

       970        980        990       1000       1010       1020 
IISLSGNYCT DKKPAAINWI EGRGKSVVTE AVIPGAIVEK VLKTTVAALV ELNISKNLIG 

      1030       1040       1050       1060       1070       1080 
SAMAGSVGGF NAHAANILTA IYLATGQDPA QNVESSNCIT LMKAVNDTKD LHISCTMPSI 

      1090       1100       1110       1120       1130       1140 
EVGTIGGGTI LPPQQSMLDM LGVRGPHPTE PGKNAQRLAR IICAAVMAGE LSLCAALAAG 

      1150       1160       1170 
HLVKAHMAHN RGTQAPTITS GPAPSTGTEP GTCIKS
Q12649 in FASTA format

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View entry in raw text format (no links)
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