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UniProtKB/Swiss-Prot entry Q12641


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CR_NEUCR
Primary accession number Q12641
Secondary accession number Q7RV72
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on December 4, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 54)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase
Synonyms P5C reductase
P5CR
EC 1.5.1.2
Gene name
Name: pro-1
ORFNames: NCU06471
From
Neurospora crassa [TaxID: 5141] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1007/BF02191601; PubMed=7565596 [NCBI, ExPASy, EBI, Israel, Japan]
Davis C.R., McPeek M.A., McClung C.R.;
"Molecular characterization of the proline-1 (pro-1) locus of Neurospora crassa, which encodes delta 1-pyrroline-5-carboxylate reductase.";
Mol. Gen. Genet. 248:341-350(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
"The genome sequence of the filamentous fungus Neurospora crassa.";
Nature 422:859-868(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U30317; AAA83568.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000027; EAA28126.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S57863; S57863.
RefSeq XP_957362.2; -.
3D structure databases
ModBase Q12641.
Enzyme and pathway databases
BioCyc NCRA-XX3-01:NCRA-XX3-01-001330-MON; -.
Family and domain databases
InterPro IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
PANTHER PTHR11645; P5CR; 2.
Pfam PF03807; F420_oxidored; 2.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
BLOCKS Q12641.
Genome annotation databases
GeneID 3873483; -.
NMPDR fig|5141.1.peg.4259; -.
Other
ProtoNet Q12641.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   332  332     Pyrroline-5-carboxylate reductase. PRO_0000187326
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 34215 Da [This is the MW of the unprocessed precursor] CRC64: 605F1E2FD6FEEB86 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAAPQVKSSS ELTMAVLGCG TMGISILSGI LSSLSSIAQD PSPPPTNPPA LPRHFIATVR 

        70         80         90        100        110        120 
SPSSVAKVES ALSPLVKPSV STLRVLQSTS NVSAAAEADI ILLGCKPYMV SGLLSASGMK 

       130        140        150        160        170        180 
DALTVKHTEG HARSQKIIIS ICAGVTVPDL ERVLREDVGL SADNLPIVVR AMPNTASKIR 

       190        200        210        220        230        240 
ESMTVINTVD PPLPDTVTEL LTWIFERIGE VVYLPPHLMD ACTSLCASGT AFFALMMEAA 

       250        260        270        280        290        300 
ADGGVAMGLP RAEANRMAAQ TMRGAAGLVL EGEHPAILRE KVSTPGGCTI GGLLVLEEGG 

       310        320        330 
VRAAVARAVR EATVVASLLG GGGAKNVNGT RH 

Q12641 in FASTA format

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