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UniProtKB/Swiss-Prot entry Q12577

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_GIBFU
Primary accession number Q12577
Secondary accession number Q12615
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    October 14, 2008 (Entry version 58)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name
Name: HMGR
Synonyms: HMGA
From
Gibberella fujikuroi (Bakanae and foot rot disease fungus) (Fusarium moniliforme) [TaxID: 5127] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Hypocreales; Nectriaceae; Gibberella; Gibberella fujikuroi complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=m567;
DOI=10.1007/s002940050174; PubMed=9000379 [NCBI, ExPASy, EBI, Israel, Japan]
Woitek S., Unkles S.E., Kinghorn J.R., Tudzynski B.;
"3-hydroxy-3-methylglutaryl-CoA reductase gene of Gibberella fujikuroi: isolation and characterization.";
Curr. Genet. 31:38-47(1997).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 613-718.
STRAIN=IMI 58289;
Corrochano L.M., Avalos J.;
"Cloning a segment of the gene encoding 3-hydroxy-3-methyglutaryl coenzyme A reductase in Phycomyces blakesleeanus and Gibberella fujikuroi.";
Exp. Mycol. 16:167-171(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X94307; CAA63970.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
X58370; CAA41261.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S17343; S17343.
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase Q12577.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
IPR000731; SSD_5TM.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PS50156; SSD; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q12577.
Other
ProtoNet Q12577.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol biosynthesis; Endoplasmic reticulum; Glycoprotein; Lipid synthesis; Membrane; NADP; Oxidoreductase; Steroid biosynthesis; Sterol biosynthesis; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   976  976     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114452
TRANSMEM   37    57  21     Potential. 
TRANSMEM   65    85  21     Potential. 
TRANSMEM   91   111  21     Potential. 
TRANSMEM   170   190  21     Potential. 
TRANSMEM   194   214  21     Potential. 
TRANSMEM   274   294  21     Potential. 
TRANSMEM   402   422  21     Potential. 
REGION   423   517  95     Linker. 
REGION   518   976  459     Catalytic. 
ACT_SITE   618   618        Charge relay system (By similarity). 
ACT_SITE   752   752        Charge relay system (By similarity). 
ACT_SITE   828   828        Charge relay system (By similarity). 
ACT_SITE   924   924        Proton donor (By similarity). 
CARBOHYD   451   451        N-linked (GlcNAc...) (Potential). 
CARBOHYD   498   498        N-linked (GlcNAc...) (Potential). 
CARBOHYD   682   682        N-linked (GlcNAc...) (Potential). 
CARBOHYD   928   928        N-linked (GlcNAc...) (Potential). 
CONFLICT   686   686        R -> S (in Ref. 2; CAA41261). 
Sequence information
Length: 976 AA [This is the length of the unprocessed precursor] Molecular weight: 105395 Da [This is the MW of the unprocessed precursor] CRC64: 2B8F1C9F3CB5A714 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDHEGCQGQH PQQCCQWVSN AWSEFLDLLK NAETLDIVIM LLGYIAMHLT FVSLFLSMRK 

        70         80         90        100        110        120 
MGSKFWLGIC TLFSSVFAFL FGLVVTTKLG VPISVILLSE GLPFLVVTIG FEKNIVLTRA 

       130        140        150        160        170        180 
VMSHAIEHRR IQAQNSKSGK RSPDGSTQNM IQYAVQAAIK EKGFEIIRDY AIEIVILVIG 

       190        200        210        220        230        240 
AASGVQGGLQ QFCFLAAWTL FFDFILLFTF YTAILSIKLR STVSSVMSIC VWPLRMMASR 

       250        260        270        280        290        300 
RVAENVAKGD DELNRVRGDA PLFGRKSSSI PKFKVLMILG FIFVNIVNIC SIPFRNPSSM 

       310        320        330        340        350        360 
STIRTWASSL GGVIAPLSVD PFKVASNGLD AILPTAKSNN RPTLVTVLTP IKYELEYPSI 

       370        380        390        400        410        420 
HYALGSAASN PAYNDAFHHH FQGYGVGGRM VGGILKSLED PVLSKWIVIA LALSVALNGY 

       430        440        450        460        470        480 
LFNVARWGIK DPNVPEHNID RNELARAREF NDTGSATLPL GEYVPPTPMR TQPSTPAITD 

       490        500        510        520        530        540 
DEAEGLHMTK ARPANLPNRS NEELEKLLSE NALREMTDEE VISLSMRGKI PGYALEKTLG 

       550        560        570        580        590        600 
DFTRAVKIRR SIIARNKAAA DITHSLDRSK LPYENYNWER FFGACCENVI GYMPLPVGVA 

       610        620        630        640        650        660 
GPLVIDGQSY FIPMATTEGV LVASASRGCK AINSGGGAIT VLTADGMTRG PCVAFETLER 

       670        680        690        700        710        720 
AGAAKLWLDS EAGQDMMKKA FNSTSRFARL QSMKTALAGT NLYIRFKTTT GDAMGMNMIS 

       730        740        750        760        770        780 
KGVEHALSVM ANDGGFDDMQ IISVSGNYCT DKKAAALNWI DGRGKGVVAE AIIPGEVVRS 

       790        800        810        820        830        840 
VLKSDVDSLV ELNVAKNLIG SAMAGSVGGF NAHAANIVAA IFLATGQDPA QVVESANCIT 

       850        860        870        880        890        900 
IMKNLNGALQ ISVSMPSLEV GTLGGGTILE PQGAMLDILG VRGSHPTNPG DNARRLARII 

       910        920        930        940        950        960 
GAAVLAGELS LCSALAAGHL VRAHMQHNRS AAPSRSTTPG SSHDARLTGH DQCPRALSVN 

       970 
NVDERRRYSE VKAIDE
Q12577 in FASTA format

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