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UniProtKB/Swiss-Prot entry Q12572

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LYS2_CANAL
Primary accession number Q12572
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on July 15, 1999 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 50)
Name and origin of the protein
Protein name L-aminoadipate-semialdehyde dehydrogenase large subunit
Synonyms EC 1.2.1.31
Alpha-aminoadipate reductase
Alpha-AR
Gene name
Name: LYS2
From
Candida albicans (Yeast) [TaxID: 5476] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 11651 / B792 / 171D;
DOI=10.1007/s002940050336; PubMed=9560434 [NCBI, ExPASy, EBI, Israel, Japan]
Suvarna K., Seah L., Bhattacherjee V., Bhattacharjee J.K.;
"Molecular analysis of the LYS2 gene of Candida albicans: homology to peptide antibiotic synthetases and the regulation of the alpha-aminoadipate reductase.";
Curr. Genet. 33:268-275(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U58133; AAC02241.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P14687; 1AMU. [HSSP ENTRY / PDB]
ModBase Q12572.
Family and domain databases
InterPro IPR010071; AA_adenyl_dom.
IPR000873; AMP-dep_Synth/Lig.
IPR014397; L-NH2adipate-semiAld_DH_lsu.
IPR013120; Male_sterile_NAD-bd.
IPR006163; Phsphopanteth_bd.
IPR006162; Ppantne_S.
IPR010080; Thioester_reductase.
Graphical view of domain structure.
Pfam PF00501; AMP-binding; 1.
PF07993; NAD_binding_4; 1.
PF00550; PP-binding; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF001617; Alpha-AR; 1.
TIGRFAMs TIGR01733; AA-adenyl-dom; 1.
TIGR03443; alpha_am_amid; 1.
TIGR01746; Thioester-redct; 1.
PROSITE PS50075; ACP_DOMAIN; 1.
PS00455; AMP_BINDING; 1.
PS00012; PHOSPHOPANTETHEINE; FALSE_NEG.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q12572.
Other
ProtoNet Q12572.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Lysine biosynthesis; NADP; Oxidoreductase; Phosphopantetheine.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1391  1391     L-aminoadipate-semialdehyde dehydrogenase large subunit. PRO_0000193149
DOMAIN   852    902  51     Acyl carrier. 
BINDING   884    884        Phosphopantetheine (covalent) (Potential). 
Sequence information
Length: 1391 AA [This is the length of the unprocessed precursor] Molecular weight: 154741 Da [This is the MW of the unprocessed precursor] CRC64: B7E641866235BCDD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTDFWLNYLD NPTLSVLPHD FLKPANNKSV EGTYTFNIDN GSTDFKFGLA VFAALVYRLT 

        70         80         90        100        110        120 
GDEDIVIATD ESANTPEFIV RLNLTPELTF QELVSKITKE YENNISQINY KALSEVSHRI 

       130        140        150        160        170        180 
KEAKGLDENP GLFRLSYQHA HSNQQLNTTV EGSIRDLAIY TDGTKFTIYY NALLYSHERV 

       190        200        210        220        230        240 
VICGEQFAQL TTVSGDTDTV IAEVFLITDF HKKNLPDPTI DLDWSGYRGA IQEIFMDNAN 

       250        260        270        280        290        300 
KHPDRTCVVE TVSFLESNSK TRNFSYHKLI KLLIVVGNYL KETGIKKGDI VMIYAYRGVD 

       310        320        330        340        350        360 
LMIAVMGVLK AGATFSVIDP AYPPARQNIY LSVAKPKGLI GLEKAGTLDQ LVVDYISNEL 

       370        380        390        400        410        420 
DVVSTIPQLK VQDDGTLVGG KLEGADNDCL NDYQKFKDQP AGVIVGPDSR PTLSFTSGSE 

       430        440        450        460        470        480 
GIPKGVLGRH YSLAYYFPWM AKRFRLSEKD KFTILSGIAH DPIQRDMFTP LFLGAQLLVP 

       490        500        510        520        530        540 
TADDIGTPGK LADWMAKYGA TVTHLTLAMG QLLSAQATTA IPSLHAFFVG DILTKRDCLR 

       550        560        570        580        590        600 
LQSLAENVFI VNMLWSLSQT QRSVSYFEIK SRKADPTYLK NLKAVMPAGT GMHNVQLLVV 

       610        620        630        640        650        660 
NRNDRSQTCG VGEVGEIYVR AAGLAEGYRG LPDLNAAKFI TNWYVNPDKW IEQDEANKKS 

       670        680        690        700        710        720 
SETSERTWSV KPRDRMYRSG DLGRYFSDGN VECCGRADDQ VKIRGFRIEL GEIDTHLSQH 

       730        740        750        760        770        780 
PLVRENVTLV RRDKNEEPTL ISYIVPKDSP ELKTFFADVD FPLKKSNDPI VKGLVAYREL 

       790        800        810        820        830        840 
IKDIKGYLKK KLASYAIPTI IVPLVKLPLN PNGKVDKPKL PFPDTAQLAA VAKLSVSSHD 

       850        860        870        880        890        900 
AQAAEEENLT KLEEQIRDLW LDVLPNRPAT ISKDDSFFDL GSHSILGTRI FTYEQKLNVE 

       910        920        930        940        950        960 
IPLVSFKGDQ RRPRFPIGLS RYNYSRREQR CRRFLKAKTY TMRRSKELSK ELSKSALLES 

       970        980        990       1000       1010       1020 
YSSLKQLPSG SVNVFVTGAT GFLGSFIVRD LLTARNKNLD IKVYAHVRAS SKEAGLQRLR 

      1030       1040       1050       1060       1070       1080 
QTGITYGIWD ENWAEKIEIV LGDLSKEKFG LDNSQWSDLT NSIDVLFTMV LCHWVYPYSQ 

      1090       1100       1110       1120       1130       1140 
LRMLNVIGTI NVFNMAGEVK LKFFSFVSST SALDTDYFVN LSDELLAQGK NGISEADDLQ 

      1150       1160       1170       1180       1190       1200 
GSAKGLGNGY GQSKWAAEYI IRRAGERGLK GCITRPGYVA GFSKTGASNT DDFLLRMLKG 

      1210       1220       1230       1240       1250       1260 
SAELGLYPDI TNNVNMVPVD HVARVVTATA LNPPSSEELT VAHVTGHPRI LFNNFLGCLK 

      1270       1280       1290       1300       1310       1320 
AYGYEINPAD YPVWTSALEK FVIEESKESA LFPLLHFVLD NLPQDTKAPE LDDSNAAKSL 

      1330       1340       1350       1360       1370       1380 
KQDSKYTGED FSAGKGVDLD QTGVYISYLI KIGFLPKPTG TGEKKLPEVE ISDESLKLIS 

      1390 
GGAGARGSAA K
Q12572 in FASTA format

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