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UniProtKB/Swiss-Prot entry Q11141

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name P5CR_MYCTU
Primary accession number Q11141
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1996
Sequence was last modified on October 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 58)
Name and origin of the protein
Protein name Pyrroline-5-carboxylate reductase
Synonyms P5C reductase
P5CR
EC 1.5.1.2
Gene name
Name: proC
OrderedLocusNames: Rv0500, MT0520
ORFNames: MTCY20G9.26
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842573; CAB00926.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK44743.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR G70745; G70745.
RefSeq NP_215014.1; -.
NP_334929.1; -.
3D structure databases
ModBase Q11141.
Organism-specific databases
TubercuList Rv0500; -.
Family and domain databases
InterPro IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11645; P5CR; 1.
Pfam PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000193; Pyrrol-5-carb_rd; 1.
TIGRFAMs TIGR00112; proC; 1.
PROSITE PS00521; P5CR; 1.
BLOCKS Q11141.
Genome annotation databases
GeneID 887256; -.
923905; -.
GenomeReviews AE000516_GR; MT0520.
AL123456_GR; Rv0500.
KEGG mtc:MT0520; -.
mtu:Rv0500; -.
TIGR MT0520; -.
Phylogenomic databases
HOGENOM Q11141; -.
Other
ProtoNet Q11141.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   295  295     Pyrroline-5-carboxylate reductase. PRO_0000187294
Sequence information
Length: 295 AA [This is the length of the unprocessed precursor] Molecular weight: 30172 Da [This is the MW of the unprocessed precursor] CRC64: F95C3F407BE5408F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLFGMARIAI IGGGSIGEAL LSGLLRAGRQ VKDLVVAERM PDRANYLAQT YSVLVTSAAD 

        70         80         90        100        110        120 
AVENATFVVV AVKPADVEPV IADLANATAA AENDSAEQVF VTVVAGITIA YFESKLPAGT 

       130        140        150        160        170        180 
PVVRAMPNAA ALVGAGVTAL AKGRFVTPQQ LEEVSALFDA VGGVLTVPES QLDAVTAVSG 

       190        200        210        220        230        240 
SGPAYFFLLV EALVDAGVGV GLSRQVATDL AAQTMAGSAA MLLERMEQDQ GGANGELMGL 

       250        260        270        280        290 
RVDLTASRLR AAVTSPGGTT AAALRELERG GFRMAVDAAV QAAKSRSEQL RITPE
Q11141 in FASTA format

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