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UniProtKB/Swiss-Prot entry Q10680


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COBK_MYCTU
Primary accession number Q10680
Secondary accession numbers None
Integrated into Swiss-Prot on July 15, 1998
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Precorrin-6A reductase
Synonyms EC 1.3.1.54
Precorrin-6X reductase
Gene name
Name: cobK
OrderedLocusNames: Rv2070c, MT2130
ORFNames: MTCY49.09c
From
Mycobacterium tuberculosis [TaxID: 1773] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 25618 / H37Rv;
DOI=10.1038/31159; PubMed=9634230 [NCBI, ExPASy, EBI, Israel, Japan]
Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.";
Nature 393:537-544(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CDC 1551 / Oshkosh;
DOI=10.1128/JB.184.19.5479-5490.2002; PubMed=12218036 [NCBI, ExPASy, EBI, Israel, Japan]
Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
"Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.";
J. Bacteriol. 184:5479-5490(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX842578; CAA98217.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE000516; AAK46410.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A70765; A70765.
RefSeq NP_216586.1; -.
NP_336596.1; -.
3D structure databases
ModBase Q10680.
Organism-specific databases
TubercuList Rv2070c; -.
Family and domain databases
InterPro IPR003723; Cbl_synth_CobK/CbiJ.
Graphical view of domain structure.
Pfam PF02571; CbiJ; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR00715; precor6x_red; 1.
PROSITE PS51014; COBK_CBIJ; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q10680.
Genome annotation databases
GeneID 887566; -.
924600; -.
GenomeReviews AE000516_GR; MT2130.
AL123456_GR; Rv2070c.
KEGG mtc:MT2130; -.
mtu:Rv2070c; -.
TIGR MT2130; -.
Phylogenomic databases
HOGENOM Q10680; -.
Other
LinkHub Q10680; -.
ProtoNet Q10680.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cobalamin biosynthesis; Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   244  244     Precorrin-6A reductase. PRO_0000135919
Sequence information
Length: 244 AA [This is the length of the unprocessed precursor] Molecular weight: 25737 Da [This is the MW of the unprocessed precursor] CRC64: 946A3F5E7740807C [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTRVLLLGGT AEGRALAKEL HPHVEIVSSL AGRVPNPALP IGPVRIGGFG GVEGLRGWLR 

        70         80         90        100        110        120 
EERIDAVVDA THPFAVTITA HAAQVCGELG LPYLVLARPP WDPGTAIIAV SDIEAADVVA 

       130        140        150        160        170        180 
EQGYSRVFLT TGRSGIAAFA NSDAWFLIRV VTAPDGTALP RRHKLVLSRG PYGYHDEFAL 

       190        200        210        220        230        240 
LREQRIDALV TKNSGGKMTR AKLDAAAALG ISVVMIARPL LPAGVAAVDS VHRAAMWVAG 


LPSR 

Q10680 in FASTA format

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