ID   ASPD_UNCMA              Reviewed;         270 AA.
AC   Q0W7E0;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-NOV-2008, entry version 18.
DE   RecName: Full=Probable L-aspartate dehydrogenase;
DE            EC=1.4.1.21;
GN   Name=nadX; OrderedLocusNames=UNCMA_24780; ORFNames=RCIX226;
OS   Uncultured methanogenic archaeon RC-I.
OC   Archaea; Euryarchaeota; environmental samples.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the
RT   rice rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Specifically catalyzes the NAD or NADP-dependent
CC       dehydrogenation of L-aspartate to iminoaspartate (By similarity).
CC   -!- CATALYTIC ACTIVITY: L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate
CC       + NH(3) + NAD(P)H.
CC   -!- PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis;
CC       iminoaspartate from L-aspartate (dehydrogenase route): step 1/1.
CC   -!- MISCELLANEOUS: The iminoaspartate product is unstable in aqueous
CC       solution and can decompose to oxaloacetate and ammonia (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the L-aspartate dehydrogenase family.
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DR   EMBL; AM114193; CAJ35703.1; -; Genomic_DNA.
DR   RefSeq; YP_685029.1; -.
DR   GeneID; 5143303; -.
DR   GenomeReviews; AM114193_GR; UNCMA_24780.
DR   KEGG; rci:RCIX226; -.
DR   GO; GO:0033735; F:aspartate dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0051287; F:NAD binding; IEA:HAMAP.
DR   GO; GO:0050661; F:NADP binding; IEA:HAMAP.
DR   GO; GO:0016639; F:oxidoreductase activity, acting on the CH-N...; IEA:HAMAP.
DR   GO; GO:0009435; P:NAD biosynthetic process; IEA:HAMAP.
DR   GO; GO:0006742; P:NADP catabolic process; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_01265; -; 1.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR002811; Asp_DHase.
DR   InterPro; IPR011182; Asp_DHase_NAD_syn.
DR   Pfam; PF01958; DUF108; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF005227; Asp_dh_NAD_syn; 1.
DR   ProDom; PD017325; Asp_dh; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NAD; NADP; Oxidoreductase;
KW   Pyridine nucleotide biosynthesis.
FT   CHAIN         1    270       Probable L-aspartate dehydrogenase.
FT                                /FTId=PRO_1000067314.
FT   ACT_SITE    221    221       By similarity.
FT   BINDING     123    123       NAD; via amide nitrogen (By similarity).
FT   BINDING     191    191       NAD (By similarity).
SQ   SEQUENCE   270 AA;  28621 MW;  62A6113535FAE704 CRC64;
     MFRIGIVGAG AIGKEIARAI DNGTVPAKLE AIYDRDTAEA TSFAASLKSK PRVLPLEELV
     EASNFVVEAA AQSAVREVAI AALSRSRSVM IMSVGALADK ELLETIRTMA KEHCCSIYLP
     SGAIGGLDAV KAASICKIDS VTITTRKPRD GLRGAPFIVR NNIDVDSMDE PTEIFSGPAA
     VAIKEFPANV NVAASLSLVG IGFERTLVRV VVDPTIKRNI HEISVRGEFG ELHTVVENVP
     ARSNPKTSFL AALSAIATLR QVCEPLKIGT
//