[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Fetal liver; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the synthesis of the excitotoxin quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. The direct product of the reaction spontaneously rearranges to QUIN (By similarity).
CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O₂ = 2-amino-3-carboxymuconate semialdehyde.
COFACTOR: Fe(2+) ion (By similarity).
SUBUNIT: Monomer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the 3-HAO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC120265; AAI20266.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001068926.1; -.

UniGene

Bt.20241

3D structure databases

ModBase

Q0VCA8.

Family and domain databases

InterPro

IPR010329; 3hydroanth_dOase.
IPR016700; 3hydroanth_dOase_met.
Graphical view of domain structure.

Pfam

PF06052; 3-HAO; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF017681; 3hydroanth_dOase_animal; 1.

TIGRFAMs

TIGR03037; anthran_nbaC; 1.

BLOCKS

Q0VCA8.

Genome annotation databases

Ensembl

ENSBTAG00000004674; Bos taurus. [Contig view]

GeneID

510602; -.

KEGG

bta:510602; -.

Phylogenomic databases

HOVERGEN

Q0VCA8; -.

Other

ProtoNet

Q0VCA8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Dioxygenase; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 286`	`286`	`3-hydroxyanthranilate 3,4-dioxygenase.`	`PRO_0000283033`
`METAL`	`47 47`		`Iron; catalytic (By similarity).`
`METAL`	`53 53`		`Iron; catalytic (By similarity).`
`METAL`	`91 91`		`Iron; catalytic (By similarity).`
`BINDING`	`43 43`		`Dioxygen (By similarity).`
`BINDING`	`53 53`		`Substrate (By similarity).`
`BINDING`	`95 95`		`Substrate (By similarity).`
`BINDING`	`105 105`		`Substrate (By similarity).`

Sequence information

Length: 286 AA [This is the length of the unprocessed precursor]

Molecular weight: 32493 Da [This is the MW of the unprocessed precursor]

CRC64: 6887DDB93B861F8E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MERPVRVKAW VEENRGSFLP PVCNKLLHQK QLKIMFVGGP NTRKDYHIEE GEEVFYQLEG 

        70         80         90        100        110        120 
DMLLRVLERG KHRDVVIRQG EIFLLPAGVP HSPQRFANTV GLVIERRRLK TELDGLRYYV 

       130        140        150        160        170        180 
GDTTDVLFEK WFYCEDLGTQ LAPIIQEFFS SEQYRTGKPN PDQLLKEPPF PLSTRSVMEP 

       190        200        210        220        230        240 
MCLEAWLDGH RKELQAGTPL SLFGDTYESQ VMVHGQGSSE GLRRDVDVWL WQLEGSSVVT 

       250        260        270        280 
MEGQRLSLTL DDSLLVPAGT LYGWERGQGS VALSVTQDPA CKKSLG

Q0VCA8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools