[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=N6; TISSUE=Ovary; NIH - Xenopus Gene Collection (XGC) project; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity).
CATALYTIC ACTIVITY: A 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-Delta⁴-steroid + reduced acceptor.
SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the steroid 5-alpha reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC122039; AAI22040.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001072539.1; -.

UniGene

Str.24988

3D structure databases

ModBase

Q0P4J9.

Organism-specific databases

Xenbase

XB-FEAT-985510; srd5a3.

Ontologies

GO:0005789;	Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005792;	Cellular component: microsome (inferred from electronic annotation from UniProtKB-KW).
GO:0003865;	Molecular function: 3-oxo-5-alpha-steroid 4-dehydrogenase activity (inferred from electronic annotation from EC).
GO:0006629;	Biological process: lipid metabolic process (inferred from electronic annotation from InterPro).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001104; 3-oxo-5_a-steroid_4-DHase_C.
Graphical view of domain structure.

Pfam

PF02544; Steroid_dh; 1.
Pfam graphical view of domain structure.

PROSITE

PS50244; S5A_REDUCTASE; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

GeneID

779994; -.

KEGG

xtr:779994; -.

Phylogenomic databases

HOVERGEN

Q0P4J9; -.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Endoplasmic reticulum; Membrane; Microsome; Oxidoreductase; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 308`	`308`	`3-oxo-5-alpha-steroid 4-dehydrogenase 3.`	`PRO_0000317706`
`TRANSMEM`	`3 23`	`21`	`Potential.`
`TRANSMEM`	`66 86`	`21`	`Potential.`
`TRANSMEM`	`121 141`	`21`	`Potential.`
`TRANSMEM`	`149 169`	`21`	`Potential.`
`TRANSMEM`	`185 205`	`21`	`Potential.`
`TRANSMEM`	`256 276`	`21`	`Potential.`

Sequence information

Length: 308 AA [This is the length of the unprocessed precursor]

Molecular weight: 35876 Da [This is the MW of the unprocessed precursor]

CRC64: FFE931DCDB0D558A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTLLALVWLL LDATFLITLL WHLLQGCKSG HSLLCSVFQD LIRYGKTKTG LQRPAWLQWF 

        70         80         90        100        110        120 
DIPKRCFWHF YCVSLIWNGC LLWILLRLLL QSVPVPEWLQ LVLHFLHAGS EPQILDRELS 

       130        140        150        160        170        180 
VILALALLWL HSLRRLLECL FVSVFSNGVI HLVQYCFGLG YYFLIGITVL TYCPLDRRTV 

       190        200        210        220        230        240 
STDNLLTQCH WYHILGLALY IWASLHQYRC HCILAGLRKS ASGNVINLNH SVPCGDWFER 

       250        260        270        280        290        300 
VSCPHYFAEL LIYVSIAVVF GLLNTIWWLV VLYVLLNQAL AALLCHEFYH EKFDTYPIHR 


KAFIPFIF

Q0P4J9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools