ID   NDUS3_PONAB             Reviewed;         263 AA.
AC   Q0MQG6;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   25-NOV-2008, entry version 16.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial;
DE            EC=1.6.5.3;
DE            EC=1.6.99.3;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 30 kDa subunit;
DE   AltName: Full=Complex I-30kD;
DE            Short=CI-30kD;
DE   Flags: Precursor;
GN   Name=NDUFS3;
OS   Pongo abelii (Sumatran orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V.,
RA   Gaut B., Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity).
CC   -!- CATALYTIC ACTIVITY: NADH + ubiquinone = NAD(+) + ubiquinol.
CC   -!- CATALYTIC ACTIVITY: NADH + acceptor = NAD(+) + reduced acceptor.
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane (By
CC       similarity). Note=Matrix and cytoplasmic side of the mitochondrial
CC       inner membrane (By similarity).
CC   -!- SIMILARITY: Belongs to the complex I 30 kDa subunit family.
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DR   EMBL; DQ885668; ABH12177.1; -; mRNA.
DR   HOVERGEN; Q0MQG6; -.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0006917; P:induction of apoptosis; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to u...; IEA:InterPro.
DR   GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
DR   GO; GO:0006800; P:oxygen and reactive oxygen species metaboli...; ISS:UniProtKB.
DR   GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010218; NADH_DH_csu.
DR   InterPro; IPR001268; NADH_DHase_Ub_30kDa_su.
DR   Pfam; PF00329; Complex1_30kDa; 1.
DR   ProDom; PD001581; Complex1_30K; 1.
DR   TIGRFAMs; TIGR01961; NuoC_fam; 1.
DR   PROSITE; PS00542; COMPLEX1_30K; 1.
PE   2: Evidence at transcript level;
KW   Electron transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain;
KW   Transit peptide; Transport; Ubiquinone.
FT   TRANSIT       1     35       Mitochondrion (By similarity).
FT   CHAIN        36    263       NADH dehydrogenase [ubiquinone] iron-
FT                                sulfur protein 3, mitochondrial.
FT                                /FTId=PRO_0000251861.
SQ   SEQUENCE   263 AA;  30168 MW;  6DC44C27645856C5 CRC64;
     MVAAVARLWW RGLLGASALT RGAGRPSVLL LPVRRESAGA DTRPTVRPRN DVAHQQLSAF
     GEYVAEILPK YVQQVQVSCF NELEVCIHPD GVIPVLTFLR DHTNAQFKSL VDLTAVDVPT
     RQNRFEIVYN LLSLRFNSRI RVKTYTDELT PIESAVSVFK AANWYEREIW DMFGVFFANH
     PDLRRILTDY GFEGHPFRKD FPLSGYVELR YDDEVKRVVA EPVELAQEFR KFDLNSPWEA
     FPVYRQPPES LKLEAGDKKP DAK
//