[1]	NUCLEOTIDE SEQUENCE [MRNA]. DOI=10.1016/j.cbpc.2005.05.002; PubMed=15967696 [NCBI, ExPASy, EBI, Israel, Japan] Fukuhara R., Kageyama T.; "Structure, gene expression, and evolution of primate glutathione peroxidases."; Comp. Biochem. Physiol. 141B:428-436(2005).

Comments

FUNCTION: Protects the hemoglobin in erythrocytes from oxidative breakdown (By similarity).
CATALYTIC ACTIVITY: 2 glutathione + H₂O₂ = glutathione disulfide + 2 H₂O.
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the glutathione peroxidase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB121000; BAF31851.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q0EF99; 12-195.

ModBase

Q0EF99.

Family and domain databases

InterPro

IPR000889; Glut_peroxidase.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PANTHER

PTHR11592; Glut_peroxidase; 1.

Pfam

PF00255; GSHPx; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000303; Glutathion_perox; 1.

PRINTS

PR01011; GLUTPROXDASE.

PROSITE

PS00460; GLUTATHIONE_PEROXID_1; 1.
PS00763; GLUTATHIONE_PEROXID_2; FALSE_NEG.
PS51355; GLUTATHIONE_PEROXID_3; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q0EF99.

Phylogenomic databases

HOVERGEN

Q0EF99; -.

Other

ProtoNet

Q0EF99.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Cytoplasm; Oxidoreductase; Peroxidase; Selenium; Selenocysteine.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 201`	`201`	`Glutathione peroxidase 1.`	`PRO_0000318642`
`ACT_SITE`	`47 47`		`By similarity.`
`NON_STD`	`47 47`		`Selenocysteine.`
`MOD_RES`	`146 146`		`N6-acetyllysine (By similarity).`

Sequence information

Length: 201 AA [This is the length of the unprocessed precursor]

Molecular weight: 21785 Da [This is the MW of the unprocessed precursor]

CRC64: E976C3CF4782BBD8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MCAAGLAAAA AQSVYAFSAR QLAGGEPVSL GSLRCKGLLI ENVASLUGTT VRDYTQMNEP 

        70         80         90        100        110        120 
QRRLGPRGLV VLGFPCNHSG HQENAKNEEI LNSLKYVRPG GGFEPNFMLF EKGEVNGAGA 

       130        140        150        160        170        180 
HTLFAFLREA LPAPSDDATA LMIDPKLITW SPVCRNDVAW NFEKFLVGPD GVPLRRYSRR 

       190        200 
FQTIDIEPDI EALLSQGPSC A

Q0EF99 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools