ID   TPH2_HORSE              Reviewed;         491 AA.
AC   Q0EAB8;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-NOV-2008, entry version 17.
DE   RecName: Full=Tryptophan 5-hydroxylase 2;
DE            EC=1.14.16.4;
DE   AltName: Full=Tryptophan 5-monooxygenase 2;
GN   Name=TPH2;
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Momozawa Y., Takeuchi Y., Mori Y.;
RT   "Equus caballus tryptophan hydroxylase 2 (TPH2), mRNA.";
RL   Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: L-tryptophan + tetrahydrobiopterin + O(2) = 5-
CC       hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
CC   -!- COFACTOR: Fe(2+) ion (By similarity).
CC   -!- PATHWAY: Aromatic compound metabolism; serotonin biosynthesis;
CC       serotonin from L-tryptophan: step 1/2.
CC   -!- SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid
CC       hydroxylase family.
CC   -!- SIMILARITY: Contains 1 ACT domain.
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DR   EMBL; AB264323; BAF32950.1; -; mRNA.
DR   RefSeq; NP_001075252.1; -.
DR   UniGene; Eca.12475; -.
DR   SMR; Q0EAB8; 152-440.
DR   GeneID; 100009684; -.
DR   HOVERGEN; Q0EAB8; -.
DR   GO; GO:0016597; F:amino acid binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004510; F:tryptophan 5-monooxygenase activity; IEA:InterPro.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0006587; P:serotonin biosynthetic process from tryptophan; IEA:UniProtKB-KW.
DR   InterPro; IPR001273; Aaa_hydroxylase.
DR   InterPro; IPR002912; ACT_bd.
DR   InterPro; IPR005963; Tyr_5_mOase.
DR   Gene3D; G3DSA:1.10.800.10; Aaa_hydroxylase; 1.
DR   PANTHER; PTHR11473; Aaa_hydroxylase; 1.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00351; Biopterin_H; 1.
DR   ProDom; PD002559; Aaa_hydroxylase; 1.
DR   TIGRFAMs; TIGR01270; Trp_5_monoox; 1.
DR   PROSITE; PS00367; BIOPTERIN_HYDROXYL; 1.
PE   2: Evidence at transcript level;
KW   Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein;
KW   Serotonin biosynthesis.
FT   CHAIN         1    491       Tryptophan 5-hydroxylase 2.
FT                                /FTId=PRO_0000260319.
FT   DOMAIN       65    137       ACT.
FT   METAL       319    319       Iron (By similarity).
FT   METAL       324    324       Iron (By similarity).
FT   METAL       364    364       Iron (By similarity).
FT   MOD_RES     383    383       Phosphoserine (By similarity).
FT   MOD_RES     393    393       Phosphoserine (By similarity).
SQ   SEQUENCE   491 AA;  56087 MW;  50DDC8CC992C752E CRC64;
     MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGNLTVNKSN SGKNDDKKGN KGSSRSETAP
     DSGKTAVVFS LRNEVGGLVK ALKLFQEKHV NMVHIESRKS RRRSSEVEIF VDCECGKTEF
     NELIQLLKFQ TTIVTLNPPE NIWTEEEELE DVPWFPRKIS ELDKCSHRVL MYGSELDADH
     PGFKDNVYRQ RRKYFVDVAM SYKYGQPIPR VEYTEEETKT WGVVFRELSR LYPTHACQEY
     LKNFPLLTKY CGYREDNVPQ LEDVSMFLKE RSGFAVRPVA GYLSPRDFLA GLAYRVFHCT
     QYVRHSSDPL YTPEPDTCHE LLGHVPLLAD PKFAQFSQEI GLASLGASDE DVQKLATCYF
     FTIEFGLCKQ EGQLRAYGAG LLSSIGELKH ALSDKACVKA FDPKTTCLQE CLITTFQEAY
     FVSESFEEAK EKMREFAKSI TRPFSVHFNP YTQSVEVLKD SRSIESVVQD LRSDLNTVCD
     ALNKMNQYLG V
//