[1]	NUCLEOTIDE SEQUENCE [MRNA]. Momozawa Y., Takeuchi Y., Mori Y.; "Equus caballus tryptophan hydroxylase 2 (TPH2), mRNA."; Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-tryptophan + tetrahydrobiopterin + O₂ = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
COFACTOR: Fe(2+) ion (By similarity).
PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2 .
SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
SIMILARITY: Contains 1 ACT domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB264323; BAF32950.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001075252.1; -.

UniGene

Eca.12475

3D structure databases

SMR

Q0EAB8; 152-440.

ModBase

Q0EAB8.

Family and domain databases

InterPro

IPR001273; Aaa_hydroxylase.
IPR002912; ACT_bd.
IPR005963; Tyr_5_mOase.
Graphical view of domain structure.

Gene3D

G3DSA:1.10.800.10; Aaa_hydroxylase; 1.

PANTHER

PTHR11473; Aaa_hydroxylase; 1.

Pfam

PF01842; ACT; 1.
PF00351; Biopterin_H; 1.
Pfam graphical view of domain structure.

ProDom

PD002559; Aaa_hydroxylase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01270; Trp_5_monoox; 1.

PROSITE

PS00367; BIOPTERIN_HYDROXYL; 1.

BLOCKS

Q0EAB8.

Genome annotation databases

GeneID

100009684; -.

Phylogenomic databases

HOVERGEN

Q0EAB8; -.

Other

ProtoNet

Q0EAB8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Iron; Metal-binding; Monooxygenase; Oxidoreductase; Phosphoprotein; Serotonin biosynthesis.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 491`	`491`	`Tryptophan 5-hydroxylase 2.`	`PRO_0000260319`
`DOMAIN`	`65 137`	`73`	`ACT.`
`METAL`	`319 319`		`Iron (By similarity).`
`METAL`	`324 324`		`Iron (By similarity).`
`METAL`	`364 364`		`Iron (By similarity).`
`MOD_RES`	`383 383`		`Phosphoserine (By similarity).`
`MOD_RES`	`393 393`		`Phosphoserine (By similarity).`

Sequence information

Length: 491 AA [This is the length of the unprocessed precursor]

Molecular weight: 56087 Da [This is the MW of the unprocessed precursor]

CRC64: 50DDC8CC992C752E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MQPAMMMFSS KYWARRGFSL DSAVPEEHQL LGNLTVNKSN SGKNDDKKGN KGSSRSETAP 

        70         80         90        100        110        120 
DSGKTAVVFS LRNEVGGLVK ALKLFQEKHV NMVHIESRKS RRRSSEVEIF VDCECGKTEF 

       130        140        150        160        170        180 
NELIQLLKFQ TTIVTLNPPE NIWTEEEELE DVPWFPRKIS ELDKCSHRVL MYGSELDADH 

       190        200        210        220        230        240 
PGFKDNVYRQ RRKYFVDVAM SYKYGQPIPR VEYTEEETKT WGVVFRELSR LYPTHACQEY 

       250        260        270        280        290        300 
LKNFPLLTKY CGYREDNVPQ LEDVSMFLKE RSGFAVRPVA GYLSPRDFLA GLAYRVFHCT 

       310        320        330        340        350        360 
QYVRHSSDPL YTPEPDTCHE LLGHVPLLAD PKFAQFSQEI GLASLGASDE DVQKLATCYF 

       370        380        390        400        410        420 
FTIEFGLCKQ EGQLRAYGAG LLSSIGELKH ALSDKACVKA FDPKTTCLQE CLITTFQEAY 

       430        440        450        460        470        480 
FVSESFEEAK EKMREFAKSI TRPFSVHFNP YTQSVEVLKD SRSIESVVQD LRSDLNTVCD 

       490 
ALNKMNQYLG V

Q0EAB8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools