FUNCTION: Ring cyclization and eight-electron oxidation of 3a-(2-amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9-dicarboxylic-acid to PQQ (By similarity).
CATALYTIC ACTIVITY: 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,5,6,7,8-octahydroquinoline-2,4-dicarboxylate + 3 O₂ = 4,5-dioxo-3a,4,5,6,7,8,9,9b-octahydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H₂O₂ + 2 H₂O.
PATHWAY: Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis .
SIMILARITY: Belongs to the pqqC family.

Copyright

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Cross-references

Sequence databases

EMBL

CP000394; ABI62826.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_745749.1; -.

3D structure databases

ModBase

Q0BQS6.

Ontologies

GO:0033732;	Molecular function: pyrroloquinoline-quinone synthase activity (inferred from electronic annotation from EC).
GO:0018189;	Biological process: pyrroloquinoline quinone biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00654; -; 1.
PBIL [Tree]

InterPro

IPR016084; Haem_Oase-like_multi-hlx.
IPR011845; PQQ_synth_PqqC.
IPR004305; TENA/THI4/PQQ_synth_PqqC.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.910.10; Haem_Oase-like_multi-hlx; 1.

Pfam

PF03070; TENA_THI-4; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02111; PQQ_syn_pqqC; 1.

BLOCKS

Q0BQS6.

Genome annotation databases

GeneID

4274447; -.

GenomeReviews

CP000394_GR; GbCGDNIH1_1928.

KEGG

gbe:GbCGDNIH1_1928; -.

NMPDR

fig|391165.8.peg.1869; -.

Phylogenomic databases

HOGENOM

Q0BQS6; -.

Genome annotation databases

CMR

Q0BQS6; GbCGDNIH1_1928.

Other

ProtoNet

Q0BQS6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Oxidoreductase; PQQ biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 255`	`255`		`Pyrroloquinoline-quinone synthase.`	`PRO_1000061669`

Sequence information

Length: 255 AA [This is the length of the unprocessed precursor]

Molecular weight: 28760 Da [This is the MW of the unprocessed precursor]

CRC64: 957C05947C1C7782 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTQLHNRTAG QETNRVMTPD ELEAALRAVG AERYHNLHPF HRLLHDGALT RGQVQAWALN 

        70         80         90        100        110        120 
RYHYQASIPA KDAALLSRLP TAELRREWRR RLVDHDGTEP GTGGIARWLK LAEGVGLDAA 

       130        140        150        160        170        180 
YVESREGLLP TTRFAVDAYV TFCREKPILE AIASSLTEMF SPTIIRERVS GMLANYDWVS 

       190        200        210        220        230        240 
EETLAYFKPR LTQAPRDVDF ALAYVKEHAR TPEQQQAVIA ALRFKCDVLW SQLDALYYSY 

       250 
VAPGNIPPGA FVPEV

Q0BQS6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools