NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity).
CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
SIMILARITY: Belongs to the GST superfamily. Sigma family.
SIMILARITY: Contains 1 GST C-terminal domain.
SIMILARITY: Contains 1 GST N-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z46828; CAA86859.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

T23872; T23872.

NP_496357.1; -.

3D structure databases

PDB

1ZL9; X-ray; 2.01 A; A/B=1-207.

[ExPASy / RCSB / EBI]

PDBsum

1ZL9; -.

ModBase

Q09596.

Protein-protein interaction databases

DIP

DIP:26899N; -.

IntAct

Q09596; 30.

Organism-specific databases

WormBase

WBGene00001753; gst-5.

WormPep

R03D7.6; CE01613. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q09596; -.

Ontologies

GO:0004364;	Molecular function: glutathione transferase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR010987; Glutathione-S-Trfase_C-like.
IPR004046; GST_C.
IPR004045; GST_N.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.1050.10; GST_C_like; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 1.

Pfam

PF00043; GST_C; 1.
PF02798; GST_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS50405; GST_CTER; 1.
PS50404; GST_NTER; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

R03D7.6; Caenorhabditis elegans. [Contig view]

GeneID

187537; -.

KEGG

cel:R03D7.6; -.

NMPDR

fig|6239.3.peg.7351; -.

Other

935622; -.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

3D-structure; Complete proteome; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 207`	`207`	`Probable glutathione S-transferase 5.`	`PRO_0000185928`
`DOMAIN`	`2 81`	`80`	`GST N-terminal.`
`DOMAIN`	`83 207`	`125`	`GST C-terminal.`
`STRAND`	`4 12`	`9`
`HELIX`	`13 15`	`3`
`HELIX`	`16 25`	`10`
`STRAND`	`30 34`	`5`
`TURN`	`36 38`	`3`
`HELIX`	`39 44`	`6`
`STRAND`	`55 58`	`4`
`STRAND`	`61 64`	`4`
`HELIX`	`66 76`	`11`
`HELIX`	`84 111`	`28`
`HELIX`	`119 125`	`7`
`HELIX`	`127 145`	`19`
`STRAND`	`147 151`	`5`
`HELIX`	`157 171`	`15`
`HELIX`	`180 191`	`12`
`HELIX`	`193 201`	`9`

Sequence information

Length: 207 AA [This is the length of the unprocessed precursor]

Molecular weight: 23252 Da [This is the MW of the unprocessed precursor]

CRC64: 7FDE101B24F7468B [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVSYKLTYFN GRGAGEVSRQ IFAYAGQQYE DNRVTQEQWP ALKETCAAPF GQLPFLEVDG 

        70         80         90        100        110        120 
KKLAQSHAIA RFLAREFKLN GKTAWEEAQV NSLADQYKDY SSEARPYFYA VMGFGPGDVE 

       130        140        150        160        170        180 
TLKKDIFLPA FEKFYGFLVN FLKASGSGFL VGDSLTWIDL AIAQHSADLI AKGGDFSKFP 

       190        200 
ELKAHAEKIQ AIPQIKKWIE TRPVTPF

Q09596 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools