ID   SMA6_CAEEL              Reviewed;         636 AA.
AC   Q09488;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   16-DEC-2008, entry version 69.
DE   RecName: Full=Serine/threonine-protein kinase sma-6;
DE            EC=2.7.11.30;
DE   Flags: Precursor;
GN   Name=sma-6; ORFNames=C32D5.2;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99065496; PubMed=9847239;
RA   Krishna S., Maduzia L.L., Padgett R.W.;
RT   "Specificity of TGFbeta signaling is conferred by distinct type I
RT   receptors and their associated SMAD proteins in Caenorhabditis
RT   elegans.";
RL   Development 126:251-260(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Involved in TGF-beta pathway. May be a receptor for daf-
CC       7.
CC   -!- CATALYTIC ACTIVITY: ATP + [receptor-protein] = ADP + [receptor-
CC       protein] phosphate.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (Potential).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC   -!- SIMILARITY: Contains 1 GS domain.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AF104017; AAD12261.1; -; mRNA.
DR   EMBL; U23511; AAC46790.1; -; Genomic_DNA.
DR   PIR; T15734; T15734.
DR   RefSeq; NP_495271.1; -.
DR   UniGene; Cel.5733; -.
DR   HSSP; P36897; 1IAS.
DR   Ensembl; C32D5.2; Caenorhabditis elegans.
DR   GeneID; 174044; -.
DR   KEGG; cel:C32D5.2; -.
DR   NMPDR; fig|6239.3.peg.5860; -.
DR   WormBase; WBGene00004860; sma-6.
DR   WormPep; C32D5.2; CE01842.
DR   NextBio; 882265; -.
DR   ArrayExpress; Q09488; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005024; F:transforming growth factor beta receptor ac...; IEA:InterPro.
DR   GO; GO:0010171; P:body morphogenesis; IMP:WormBase.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
DR   GO; GO:0040010; P:positive regulation of growth rate; IMP:WormBase.
DR   GO; GO:0040018; P:positive regulation of multicellular organi...; IMP:WormBase.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0007178; P:transmembrane receptor protein serine/threo...; IEA:InterPro.
DR   InterPro; IPR000333; Activin_II_recpt.
DR   InterPro; IPR000472; Activin_rcpt.
DR   InterPro; IPR000719; Prot_kinase_core.
DR   InterPro; IPR017441; Protein_kinase_ATP_bd_CS.
DR   InterPro; IPR017442; Se/Thr_pkinase-rel.
DR   InterPro; IPR008271; Ser_thr_pkin_AS.
DR   InterPro; IPR003605; TGF_beta_rcpt_GS.
DR   Pfam; PF01064; Activin_recp; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   PRINTS; PR00653; ACTIVIN2R.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00467; GS; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Developmental protein; Glycoprotein;
KW   Kinase; Membrane; Nucleotide-binding; Receptor;
KW   Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
FT   SIGNAL        1     20       Potential.
FT   CHAIN        21    636       Serine/threonine-protein kinase sma-6.
FT                                /FTId=PRO_0000024432.
FT   TOPO_DOM     21    190       Extracellular (Potential).
FT   TRANSMEM    191    211       Potential.
FT   TOPO_DOM    212    636       Cytoplasmic (Potential).
FT   DOMAIN      235    264       GS.
FT   DOMAIN      265    606       Protein kinase.
FT   NP_BIND     271    279       ATP (By similarity).
FT   ACT_SITE    397    397       Proton acceptor (By similarity).
FT   BINDING     292    292       ATP (By similarity).
FT   CARBOHYD     80     80       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    184    184       N-linked (GlcNAc...) (Potential).
SQ   SEQUENCE   636 AA;  72235 MW;  3349C85944E6AE24 CRC64;
     MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP
     NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG
     SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS
     PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES
     KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED
     SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT
     TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL
     RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV
     NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG
     IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK
     EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS
//