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UniProtKB/Swiss-Prot entry Q09488

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SMA6_CAEEL
Primary accession number Q09488
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on February 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 66)
Name and origin of the protein
Protein name Serine/threonine-protein kinase sma-6 [Precursor]
Synonym EC 2.7.11.30
Gene name
Name: sma-6
ORFNames: C32D5.2
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Bristol N2;
PubMed=9847239 [NCBI, ExPASy, EBI, Israel, Japan]
Krishna S., Maduzia L.L., Padgett R.W.;
"Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans.";
Development 126:251-260(1999).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF104017; AAD12261.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U23511; AAC46790.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T15734; T15734.
RefSeq NP_495271.1; -.
UniGene Cel.5733
3D structure databases
HSSP P36897; 1IAS. [HSSP ENTRY / PDB]
ModBase Q09488.
Organism-specific databases
WormBase WBGene00004860; sma-6.
WormPep C32D5.2; CE01842. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q09488; -.
Ontologies
GO
GO:0010171; Biological process: body morphogenesis (inferred from mutant phenotype from WormBase).
GO:0040024; Biological process: dauer larval development (inferred from genetic interaction from WormBase).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
GO:0040018; Biological process: positive regulation of multicellular organism growth (inferred from mutant phenotype from WormBase).
GO:0000003; Biological process: reproduction (inferred from mutant phenotype from WormBase).
GO:0045138; Biological process: tail tip morphogenesis (inferred from genetic interaction from WormBase).
QuickGo view.
Family and domain databases
InterPro IPR000333; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR000719; Prot_kinase_core.
IPR017441; Protein_kinase_ATP_bd_CS.
IPR017442; Se/Thr_pkinase-rel.
IPR008271; Ser_thr_pkin_AS.
IPR003605; TGF_beta_rcpt_GS.
Graphical view of domain structure.
Pfam PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
PF08515; TGF_beta_GS; 1.
Pfam graphical view of domain structure.
PRINTS PR00653; ACTIVIN2R.
ProDom PD000001; Prot_kinase; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00467; GS; 1.
SMART graphical view of domain structure.
PROSITE PS51256; GS; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q09488.
Genome annotation databases
Ensembl C32D5.2; Caenorhabditis elegans. [Contig view]
GeneID 174044; -.
KEGG cel:C32D5.2; -.
NMPDR fig|6239.3.peg.5860; -.
Other
ProtoNet Q09488.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
ATP-binding; Complete proteome; Developmental protein; Glycoprotein; Kinase; Membrane; Nucleotide-binding; Receptor; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    20  20     Potential. 
CHAIN   21   636  616     Serine/threonine-protein kinase sma-6. PRO_0000024432
TOPO_DOM   21   190  170     Extracellular (Potential). 
TRANSMEM   191   211  21     Potential. 
TOPO_DOM   212   636  425     Cytoplasmic (Potential). 
DOMAIN   235   264  30     GS. 
DOMAIN   265   606  342     Protein kinase. 
NP_BIND   271   279  9     ATP (By similarity). 
ACT_SITE   397   397        Proton acceptor (By similarity). 
BINDING   292   292        ATP (By similarity). 
CARBOHYD   80    80        N-linked (GlcNAc...) (Potential). 
CARBOHYD   184   184        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 636 AA [This is the length of the unprocessed precursor] Molecular weight: 72235 Da [This is the MW of the unprocessed precursor] CRC64: 3349C85944E6AE24 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNITFIFILI FGFFNTQKCS KDYDHFDDED LALSIPKNAI GVPKEFRQQV LKEMKLRNRP 

        70         80         90        100        110        120 
NDILKNRCYC NYDQSICGNN MTCVKQDGAA CYHAVEEVYN KAEKRMETLH KWGCATLERG 

       130        140        150        160        170        180 
SGASHLTCNS WRAAHHSPKS IGCCYEGNYC NKNLIPPAYV HHHKEKALQE KTDNPEDYDS 

       190        200        210        220        230        240 
PLENMTRGGK MFIMVFATVM SVFAVIGCIY LCITRAEEKS KARARAKTVS LKTESTYMES 

       250        260        270        280        290        300 
KSMLEDSGSG SGQAALIQRT VRQDLTIIKT IGQGRYGEVR KALYRGSYVA VKTFYTTDED 

       310        320        330        340        350        360 
SWKNERDVYQ TNMINHENIL QFVAADIWSE EDSMTKMLLI TDYHELGSLS DYLCREETLT 

       370        380        390        400        410        420 
TDEALRLIHS CICGIEHLHA AVHGTGSFRK PEIAHRDIKS KNIIVKRPNV CCIADLGLAL 

       430        440        450        460        470        480 
RYQNDKILPE KFNVQVGTKR YMAPELISNK LNPKDFSQFK MADIYSMALV MWEVAIRVEV 

       490        500        510        520        530        540 
NTCEEVLTVD ETSPDHSASS GIGESVSSSG NISRMHLQKT NVEGHSTSLK AKQHVPPFDG 

       550        560        570        580        590        600 
IVHNDPNFDE MNDVICVRRI RPPPDLAWKN VPALNELSKL MEDSWHSIPH FRHSALKLKK 

       610        620        630 
EMAELIKNPD RQNQSQRKVE FQQQDSGLVE SATNQS
Q09488 in FASTA format

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