[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Liver; Tam M.F., Liu L.-F.; Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
[2]	NUCLEOTIDE SEQUENCE [MRNA] OF 30-222. TISSUE=Liver; DOI=10.1016/0167-4781(93)90168-D; PubMed=8241281 [NCBI, ExPASy, EBI, Israel, Japan] Liu L.-F., Wu S.-H., Tam M.F.; "Nucleotide sequence of class-alpha glutathione S-transferases from chicken liver."; Biochim. Biophys. Acta 1216:332-334(1993).

Comments

FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the GST superfamily. Alpha family.
SIMILARITY: Contains 1 GST C-terminal domain.
SIMILARITY: Contains 1 GST N-terminal domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L15387; AAA16573.2; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

S43432; S43432.

NP_001001776.1; -.

3D structure databases

HSSP

P08263; 1K3O. [HSSP ENTRY / PDB]

SMR

Q08393; 3-220.

ModBase

Q08393.

Ontologies

GO:0005737;	Cellular component: cytoplasm (inferred from electronic annotation from UniProtKB-KW).
GO:0004364;	Molecular function: glutathione transferase activity (inferred from electronic annotation from InterPro).
GO:0008152;	Biological process: metabolic process (inferred from electronic annotation from InterPro).
QuickGo view.

Family and domain databases

InterPro

IPR010987; Glutathione-S-Trfase_C-like.
IPR003080; GST_alpha.
IPR004046; GST_C.
IPR004045; GST_N.
IPR012335; Thioredoxin_fold.
Graphical view of domain structure.

Gene3D

G3DSA:1.20.1050.10; GST_C_like; 1.
G3DSA:3.40.30.10; Thioredoxin_fold; 1.

PANTHER

PTHR11571:SF4; GST_alpha; 1.

Pfam

PF00043; GST_C; 1.
PF02798; GST_N; 1.
Pfam graphical view of domain structure.

PRINTS

PR01266; GSTRNSFRASEA.

PROSITE

PS50405; GST_CTER; 1.
PS50404; GST_NTER; 1.
PROSITE graphical view of domain structure (profiles).

Genome annotation databases

Ensembl

ENSGALG00000016328; Gallus gallus. [Contig view]

GeneID

414895; -.

KEGG

gga:414895; -.

Phylogenomic databases

HOGENOM

Q08393; -.

HOVERGEN

Q08393; -.

Other

ProtoNet

Q08393.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Transferase.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 222`	`222`	`Glutathione S-transferase.`	`PRO_0000185802`
`DOMAIN`	`3 83`	`81`	`GST N-terminal.`
`DOMAIN`	`85 208`	`124`	`GST C-terminal.`

Sequence information

Length: 222 AA [This is the length of the unprocessed precursor]

Molecular weight: 25414 Da [This is the MW of the unprocessed precursor]

CRC64: 7B25B823051C9B8A [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGKPKLHYT RGRGKMESIR WLLAAAGVEF EEEFIEKKED LEKLRNDGSL LFQQVPMVEI 

        70         80         90        100        110        120 
DGMKMVQSRA ILCYIAGKYN LYGKDLKERA WIDMYVEGTT DLMGMIMALP FQAADVKEKN 

       130        140        150        160        170        180 
IALITERATT RYFPVYEKAL KDHGQDYLVG NKLSWADIHL LEAILMTEEL KSDILSAFPL 

       190        200        210        220 
LQAFKGRMSN VPTIKKFLQP GSQRKPPLDE KSIANVRKIF SF

Q08393 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools