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UniProtKB/Swiss-Prot entry Q07417

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ACADS_MOUSE
Primary accession number Q07417
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 78)
Name and origin of the protein
Protein name Short-chain specific acyl-CoA dehydrogenase, mitochondrial [Precursor]
Synonyms SCAD
EC 1.3.99.2
Butyryl-CoA dehydrogenase
Gene name
Name: Acads
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/geno.1993.1438; PubMed=8276399 [NCBI, ExPASy, EBI, Israel, Japan]
Kelly C.L., Hinsdale M.E., Wood P.A.;
"Cloning and characterization of the mouse short-chain acyl-CoA dehydrogenase cDNA.";
Genomics 18:137-140(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L11163; AAA16714.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR I49605; I49605.
UniGene Mm.18759
3D structure databases
HSSP P15651; 1JQI. [HSSP ENTRY / PDB]
SMR Q07417; 28-411.
ModBase Q07417.
2D gel databases
REPRODUCTION-2DPAGE Q07417; -.
Organism-specific databases
MGI MGI:87868; Acads.
Gene expression databases
ArrayExpress Q07417; -.
CleanEx MM_ACADS; -.
GermOnline ENSMUSG00000029545; Mus musculus.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from direct assay from MGI).
QuickGo view.
Family and domain databases
InterPro IPR006091; Acyl-CoA_DHase/Oxase_M.
IPR006089; Acyl-CoA_DHase_CS.
IPR006092; Acyl-CoA_DHase_N.
IPR006090; Acyl-CoA_Oxase/DHase_1.
IPR013786; AcylCoA_DH/ox_N.
IPR013764; AcylCoA_oxidase/DH_1/2_C.
Graphical view of domain structure.
Gene3D G3DSA:2.40.110.10; Acyl_CoA_DH/ox_M; 1.
G3DSA:1.10.540.10; AcylCoA_DH/ox_N; 1.
G3DSA:1.20.140.10; AcylCoA_DH_1/2_C; 1.
Pfam PF00441; Acyl-CoA_dh_1; 1.
PF02770; Acyl-CoA_dh_M; 1.
PF02771; Acyl-CoA_dh_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00072; ACYL_COA_DH_1; 1.
PS00073; ACYL_COA_DH_2; 1.
BLOCKS Q07417.
Genome annotation databases
Ensembl ENSMUSG00000029545; Mus musculus. [Contig view]
Phylogenomic databases
HOGENOM Q07417; -.
HOVERGEN Q07417; -.
Other
SOURCE Acads; Mus musculus.
ProtoNet Q07417.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
FAD; Fatty acid metabolism; Flavoprotein; Lipid metabolism; Mitochondrion; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    24  24     Mitochondrion (By similarity). 
CHAIN   25   412  388     Short-chain specific acyl-CoA dehydrogenase, mitochondrial. PRO_0000000499
NP_BIND   152   161  10     FAD (By similarity). 
NP_BIND   185   187  3     FAD (By similarity). 
NP_BIND   365   369  5     FAD (By similarity). 
NP_BIND   394   396  3     FAD (By similarity). 
ACT_SITE   392   392        Proton acceptor (By similarity). 
BINDING   297   297        FAD (By similarity). 
Sequence information
Length: 412 AA [This is the length of the unprocessed precursor] Molecular weight: 44947 Da [This is the MW of the unprocessed precursor] CRC64: F78485BC764B79E3 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAAALLARAR GPLRRALGVR DWRRLHTVYQ SVELPETHQM LRQTCRDFAE KELVPIAAQL 

        70         80         90        100        110        120 
DREHLFPTAQ VKKMGELGLL AMDVPEELSG AGLGYLAYSI ALEEISRACA STGVIMSVNN 

       130        140        150        160        170        180 
SLYLGPILKF GSAQQKQQWI TPFTNGDKIG CFALSEPGNG SDAGAASTTA REEGDSWVLN 

       190        200        210        220        230        240 
GTKAWITNSW EASATVVFAS TDRSRQNKGI SAFLVPMPTP GLTLGKKEDK LGIRASSTAN 

       250        260        270        280        290        300 
LIFEDCRIPK ENLLGEPGMG FKIAMQTLDM GRIGIASQAL GIAQASLDCA VKYAENRNAF 

       310        320        330        340        350        360 
GAPLTKLQNI QFKLADMALA LESARLLTWR AAMLKDNKKP FTKESAMRKL AASEAATAIS 

       370        380        390        400        410 
HQAIQILGSM GYVTEMPAER YYRDARITEI YEGTSEIQRL VIAGHLLRSY RS
Q07417 in FASTA format

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