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UniProtKB/Swiss-Prot entry Q07217

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP11A_ONCMY
Primary accession number Q07217
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on October 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 49)
Name and origin of the protein
Protein name Cytochrome P450 11A1, mitochondrial [Precursor]
Synonyms EC 1.14.15.6
CYPXIA1
Cholesterol side-chain cleavage enzyme
P450(SCC)
Cholesterol desmolase
Gene name
Name: cyp11a1
From
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri) [TaxID: 8022] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
DOI=10.1016/0014-5793(93)80034-R; PubMed=8454060 [NCBI, ExPASy, EBI, Israel, Japan]
Takahashi M., Tanaka M., Sakai N., Adachi S., Miller W.L., Nagahama Y.;
"Rainbow trout ovarian cholesterol side-chain cleavage cytochrome P450 (P450scc). cDNA cloning and mRNA expression during oogenesis.";
FEBS Lett. 319:45-48(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
S57305; AAB25804.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S32197; S32197.
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase Q07217.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0008386; Molecular function: cholesterol monooxygenase (side-chain-cleaving) activity (inferred from electronic annotation from EC).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q07217.
Phylogenomic databases
HOVERGEN Q07217; -.
Other
ProtoNet Q07217.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cholesterol metabolism; Heme; Iron; Lipid metabolism; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Steroid metabolism; Steroidogenesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    39  39     Mitochondrion (Potential). 
CHAIN   40   514  475     Cytochrome P450 11A1, mitochondrial. PRO_0000003593
METAL   458   458        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 514 AA [This is the length of the unprocessed precursor] Molecular weight: 59137 Da [This is the MW of the unprocessed precursor] CRC64: 0C6F49ECE8FF38FD [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MMVSWSVCRS SLALPACGLP SARHNSSMPV VRQALSPDNS STVQNFSEIP GLWRNGLANL 

        70         80         90        100        110        120 
YSFWKLDGFR NIHRVMVHNF NTFGPIYREK IGYYDSVNII KPEMPAILFK AEGHYPKRLT 

       130        140        150        160        170        180 
VEAWTSYRDY RNRKYGVLLK NGEDWRSNRV ILNREVISPK VLGNFVPLLD EVGQDFVARV 

       190        200        210        220        230        240 
HKKIERSGQD KWTTDLSQEL FKYALESVGS VLYGERLGLM LDYINPEAQH FIDCISLMFK 

       250        260        270        280        290        300 
TTSPMLYIPP AMLRRVGAKI WRDHVEAWDG IFNQADRCIQ NIYRTMRQDT NTHGKYPGVL 

       310        320        330        340        350        360 
ASLLMLDKLS IEDIKASVTE LMAGGVDTTS ITLLWTLYEL ARHPDLQEEL RAEVAVARQS 

       370        380        390        400        410        420 
TQGDMLQMLK MIPLVKGALK ETLRLHPVAV SLQRYITEEI VIQNYHIPCG TLVQLGLYAM 

       430        440        450        460        470        480 
GRDPDVFPRP EKYLPSRWLR TENQYFRSLG FGFGPRQCLG RRIAETEMQL FLIHMLENFR 

       490        500        510 
VDKQRQVEVH STFELILLPE KPILLTLKPL KSGQ
Q07217 in FASTA format

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