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UniProtKB/Swiss-Prot entry Q07116

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SUOX_RAT
Primary accession number Q07116
Secondary accession number Q6P6W0
Integrated into Swiss-Prot on October 1, 1994
Sequence was last modified on July 10, 2007 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 77)
Name and origin of the protein
Protein name Sulfite oxidase, mitochondrial [Precursor]
Synonym EC 1.8.3.1
Gene name
Name: Suox
From
Rattus norvegicus (Rat) [TaxID: 10116] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
 NUCLEOTIDE SEQUENCE [MRNA] OF 43-546.
TISSUE=Liver;
PubMed=8276806 [NCBI, ExPASy, EBI, Israel, Japan]
Garrett R.M., Rajagopalan K.V.;
"Molecular cloning of rat liver sulfite oxidase. Expression of a eukaryotic Mo-pterin-containing enzyme in Escherichia coli.";
J. Biol. Chem. 269:272-276(1994).
[3]
 PARTIAL PROTEIN SEQUENCE.
TISSUE=Liver;
PubMed=2249998 [NCBI, ExPASy, EBI, Israel, Japan]
Barber M.J., Neame P.J.;
"A conserved cysteine in molybdenum oxotransferases.";
J. Biol. Chem. 265:20912-20915(1990).
[4]
 PROTEIN SEQUENCE OF 187-201 AND 340-368.
TISSUE=Liver;
PubMed=3393528 [NCBI, ExPASy, EBI, Israel, Japan]
Crawford N.M., Smith M., Bellissimo D.B., Davis R.W.;
"Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains.";
Proc. Natl. Acad. Sci. U.S.A. 85:5006-5010(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC061991; AAH61991.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L05084; AAA16618.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A53107; A53107.
RefSeq NP_112389.3; -.
UniGene Rn.25720
3D structure databases
HSSP P51687; 1MJ4. [HSSP ENTRY / PDB]
ModBase Q07116.
Organism-specific databases
RGD 619994; Suox.
Gene expression databases
ArrayExpress Q07116; -.
GermOnline ENSRNOG00000005987; Rattus norvegicus.
Ontologies
GO
GO:0005758; Cellular component: mitochondrial intermembrane space (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001199; Cyt_B5.
IPR005066; MoCF_OxRdtse_dimer.
IPR008335; Mopterin_OxRdtase_euk.
IPR000572; OxRdtase_Mopterin-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.10.120.10; Cyt_B5; 1.
G3DSA:2.60.40.650; MoCF_oxrdtse_dimer; 1.
G3DSA:3.90.420.10; Oxred_molyb_bd; 1.
Pfam PF00173; Cyt-b5; 1.
PF03404; Mo-co_dimer; 1.
PF00174; Oxidored_molyb; 1.
Pfam graphical view of domain structure.
PRINTS PR00363; CYTOCHROMEB5.
PR00407; EUMOPTERIN.
ProDom PD000612; Cyt_B5; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00191; CYTOCHROME_B5_1; 1.
PS50255; CYTOCHROME_B5_2; 1.
PS00559; MOLYBDOPTERIN_EUK; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q07116.
Genome annotation databases
Ensembl ENSRNOG00000005987; Rattus norvegicus. [Contig view]
GeneID 81805; -.
KEGG rno:81805; -.
Phylogenomic databases
HOVERGEN Q07116; -.
Other
ProtoNet Q07116.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Direct protein sequencing; Heme; Iron; Metal-binding; Mitochondrion; Molybdenum; Oxidoreductase; Phosphoprotein; Transit peptide.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
TRANSIT   1    80  80     Mitochondrion. 
CHAIN   81   546  466     Sulfite oxidase, mitochondrial. PRO_0000006484
DOMAIN   83   162  80     Cytochrome b5 heme-binding. 
REGION   166   182  17     Hinge (By similarity). 
REGION   183   546  364     Molybdenum-pterin domain (By similarity). 
REGION   216   220  5     Molybdenum-pterin-binding (By similarity). 
REGION   321   323  3     Molybdenum-pterin-binding (By similarity). 
REGION   367   380  14     Molybdenum-pterin-binding (By similarity). 
METAL   119   119        Iron (heme axial ligand) (By similarity). 
METAL   144   144        Iron (heme axial ligand) (By similarity). 
METAL   265   265        Molybdenum-pterin (By similarity). 
METAL   318   318        Molybdenum-pterin (By similarity). 
MOD_RES   286   286        Phosphothreonine (By similarity). 
CONFLICT   98    98        K -> Q (in Ref. 2; AAA16618). 
CONFLICT   178   178        S -> T (in Ref. 3; AA sequence). 
CONFLICT   294   294        W -> R (in Ref. 3; AA sequence). 
CONFLICT   318   318        C -> Q (in Ref. 3; AA sequence). 
CONFLICT   338   338        A -> G (in Ref. 3; AA sequence). 
CONFLICT   362   362        H -> S (in Ref. 3 and 4). 
CONFLICT   394   396        SHW -> HYL (in Ref. 3; AA sequence). 
CONFLICT   432   432        Q -> V (in Ref. 3; AA sequence). 
CONFLICT   514   514        D -> A (in Ref. 3; AA sequence). 
CONFLICT   527   527        W -> A (in Ref. 3; AA sequence). 
Sequence information
Length: 546 AA [This is the length of the unprocessed precursor] Molecular weight: 60806 Da [This is the MW of the unprocessed precursor] CRC64: B4A4E46A8F15765D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLPRLYRSVA VGLPRAIRAK STPLRLCIQA CSSSDSLKPQ HPSLTFSDDN SRTRGWKVMG 

        70         80         90        100        110        120 
TLIGLGAVLA YHDHRCRASQ ESPRIYSKED VRSHNNLKTG VWVTLGSEVF DVTKFVDLHP 

       130        140        150        160        170        180 
GGQSKLMLAA GGPLEPFWAL YAVHNQPHVR ELLAEYKIGE LNPEDRMSPP LEASDPYSND 

       190        200        210        220        230        240 
PMRHPALRIN SQRPFNAEPP PELLTESYIT PNPIFFTRNH LPVPNLDPDT YRLHVVGAPG 

       250        260        270        280        290        300 
GQSLSLSLDD LHKFPKHEVT VTLQCAGNRR SEMNKVKEVK GLEWRTGAIS TARWAGARLC 

       310        320        330        340        350        360 
DVLAQAGHRL RETEAHVCFE GLDSDPTGTA YGASIPLARA MDPQAEVLLA YEMNGQPLPR 

       370        380        390        400        410        420 
DHGFPVRVVV PGVVGARHVK WLGRVSVESE ESYSHWQRRD YKGFSPSVDW DTVDFDLAPS 

       430        440        450        460        470        480 
IQELPIQSAI TQPQDGTTVE SGEVIIKGYA WSGGGRAVIR VDVSMDGGLT WQEAELEGEE 

       490        500        510        520        530        540 
QHPRKAWAWR IWQLKAHVPA EQKELNIICK AVDDSYNVQP DTVAPIWNLR GVLSNAWHRV 


HVQVVP
Q07116 in FASTA format

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