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UniProtKB/Swiss-Prot entry Q06525

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name URN1_YEAST
Primary accession number Q06525
Secondary accession numbers None
Integrated into Swiss-Prot on June 27, 2006
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 62)
Name and origin of the protein
Protein name Pre-mRNA-splicing factor URN1
Synonym U2-U5-U6 snRNP, RES complex and NTC-interacting pre-mRNA-splicing factor 1
Gene name
Name: URN1
OrderedLocusNames: YPR152C
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169875 [NCBI, ExPASy, EBI, Israel, Japan]
Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
Nature 387:103-105(1997).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[3]
 SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02026; PubMed=14562095 [NCBI, ExPASy, EBI, Israel, Japan]
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[4]
 LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[5]
 PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-150, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M700468-MCP200; PubMed=18407956 [NCBI, ExPASy, EBI, Israel, Japan]
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U40829; AAB68289.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY692740; AAT92759.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S69038; S69038.
RefSeq NP_015478.1; -.
3D structure databases
PDB
2JUC; NMR; -; A=212-266.[ExPASy / RCSB / EBI]
PDBsum 2JUC; -.
ModBase Q06525.
Protein-protein interaction databases
DIP DIP:2017N; -.
IntAct Q06525; -.
Organism-specific databases
CYGD YPR152c; -.
SGD S000006356; URN1.
Yeast-GFP YPR152C.
Gene expression databases
ArrayExpress Q06525; -.
GermOnline YPR152C; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005681; Cellular component: spliceosome (inferred from electronic annotation from UniProtKB-KW).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0006397; Biological process: mRNA processing (inferred from electronic annotation from UniProtKB-KW).
GO:0008380; Biological process: RNA splicing (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR002713; FF.
IPR001202; WW_Rsp5_WWP.
Graphical view of domain structure.
Pfam PF01846; FF; 1.
PF00397; WW; 1.
Pfam graphical view of domain structure.
SMART SM00441; FF; 1.
SM00456; WW; 1.
SMART graphical view of domain structure.
PROSITE PS01159; WW_DOMAIN_1; 1.
PS50020; WW_DOMAIN_2; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q06525.
ProtoNet Q06525.
Genome annotation databases
Ensembl YPR152C; Saccharomyces cerevisiae. [Contig view]
GeneID 856275; -.
GenomeReviews U00094_GR; YPR152C.
KEGG sce:YPR152C; -.
NMPDR fig|4932.3.peg.6617; -.
Phylogenomic databases
HOGENOM Q06525; -.
Other
LinkHub Q06525; -.
NextBio 981586; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Spliceosome.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   465  465     Pre-mRNA-splicing factor URN1. PRO_0000244477
DOMAIN   1    32  32     WW. 
DOMAIN   214   263  50     FF. 
COMPBIAS   119   192  74     Glu-rich. 
MOD_RES   150   150        Phosphoserine. 
HELIX   216   225  10      
TURN   230   232  3      
HELIX   235   241  7      
STRAND   242   244  3      
HELIX   247   249  3      
HELIX   253   264  12      
Sequence information
Length: 465 AA [This is the length of the unprocessed precursor] Molecular weight: 54139 Da [This is the MW of the unprocessed precursor] CRC64: B32285888B7DB772 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRGEWQEFKT PAGKKYYYNK NTKQSRWEKP NLKKGSNLES NAKESQTERK PTFSLELVNG 

        70         80         90        100        110        120 
WHLIIYNDGT KLYFNDDSKE FKNDISQEDD SRCRSLIESL DKEKLVLLIG VARGYTMREE 

       130        140        150        160        170        180 
DIDKILESCN EEIHLFKRNQ DEVERKDEIS EEAGDVKSPL QESHTGLVSG YGSSSGEEDE 

       190        200        210        220        230        240 
EEDEEEDEEN EEQIVNQDIS IIDDLNRIDT DDIDERNIFF ELFDRYKLDK FSTWSLQSKK 

       250        260        270        280        290        300 
IENDPDFYKI RDDTVRESLF EEWCGERSGN ATAEESDSED NSEDDSEVLE PTKYHYLAQI 

       310        320        330        340        350        360 
VANAGTIAPD TIPQDIRKQQ KALYKAYKIK EYIPSKRDQD KFVSQLLFYY KTFDLEQRKE 

       370        380        390        400        410        420 
IFCDCLRDHE RDFTGAVESL RQDKELIDRW QTLLKAPADS SSIEDILLSI EHRCCVSPIV 

       430        440        450        460 
VTEPRYYVVG ILEKTVVWVR WLAAEVGPSS RFTPVGAGNE PINPE
Q06525 in FASTA format

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