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UniProtKB/Swiss-Prot entry Q06197

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name IDHC_SOYBN
Primary accession number Q06197
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on October 1, 1996 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 53)
Name and origin of the protein
Protein name Isocitrate dehydrogenase [NADP]
Synonyms IDH
EC 1.1.1.42
Oxalosuccinate decarboxylase
NADP(+)-specific ICDH
IDP
Gene name
Name: IDH1
From
Glycine max (Soybean) [TaxID: 3847] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; rosids; eurosids I; Fabales; Fabaceae; Papilionoideae; Phaseoleae; Glycine.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Harosoy-L1;
TISSUE=Root nodule;
DOI=10.1007/BF00027108; PubMed=8467073 [NCBI, ExPASy, EBI, Israel, Japan]
Udvardi M.K., McDermott T.R., Kahn M.L.;
"Isolation and characterization of a cDNA encoding NADP(+)-specific isocitrate dehydrogenase from soybean (Glycine max).";
Plant Mol. Biol. 21:739-752(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L12157; AAA33978.1; ALT_INIT; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P33198; 1LWD. [HSSP ENTRY / PDB]
ModBase Q06197.
Family and domain databases
InterPro IPR004790; IsoCit_DHase_NADP-dep_euk.
IPR001804; IsoCit_IM_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.718.10; IDH_IMDH; 1.
PANTHER PTHR11822; IDH_NADP_euk; 1.
Pfam PF00180; Iso_dh; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000108; IDH_NADP; 1.
ProDom PD328597; Nadp_idh_plant; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00127; nadp_idh_euk; 1.
PROSITE PS00470; IDH_IMDH; 1.
BLOCKS Q06197.
Other
ProtoNet Q06197.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glyoxylate bypass; Magnesium; Manganese; Metal-binding; NADP; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   413  413     Isocitrate dehydrogenase [NADP]. PRO_0000083585
NP_BIND   78    80  3     NADP (By similarity). 
NP_BIND   313   318  6     NADP (By similarity). 
REGION   97   103  7     Substrate binding (By similarity). 
METAL   255   255        Magnesium or manganese (By similarity). 
METAL   278   278        Magnesium or manganese (By similarity). 
BINDING   80    80        Substrate (By similarity). 
BINDING   85    85        NADP (By similarity). 
BINDING   112   112        Substrate (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   263   263        NADP (By similarity). 
BINDING   331   331        NADP; via amide nitrogen and carbonyl oxygen (By similarity). 
SITE   142   142  1     Critical for catalysis (By similarity). 
SITE   215   215  1     Critical for catalysis (By similarity). 
Sequence information
Length: 413 AA [This is the length of the unprocessed precursor] Molecular weight: 46050 Da [This is the MW of the unprocessed precursor] CRC64: 78B90E53C6D686B5 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAAFQKIKVA NPIVEMDGDE MTRVIWKSIK DKLILPFLEL DIKYYDLGLP YRDETDDKVT 

        70         80         90        100        110        120 
IESAEATLKY NVAIKCATIT PDEARVKEFG LKSMWKSPNG TIRNILNGTV FREPILCKNI 

       130        140        150        160        170        180 
PRLVPGWTKA ICIGRHAFGD QYRATDTVIK GAGKLKLVFV PEGQGEETEF EVFNFTGEGG 

       190        200        210        220        230        240 
VSLAMYNTDE SIRSFAEASM ATALEKKWPL YLSTKNTILK KYDGRFKDIF QEVYEASWKS 

       250        260        270        280        290        300 
KFEAAGIWYE HRLIDDMVAY ALKSEGGYVW ACKNYDGDVQ SDFLAQGFGS LGLMTSVLVC 

       310        320        330        340        350        360 
PDGKTIEAEA AHGTVTRHFR VHQKGGETST NSIASIFAWT RGLAHRAKLD DNAKLLDFTE 

       370        380        390        400        410 
KLEAACIGVV EAGKMTKDLA LILHGSKLSR EHYLNTEEFI DAVAAELSAR LSA
Q06197 in FASTA format

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