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UniProtKB/Swiss-Prot entry Q05788


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PNPH_YEAST
Primary accession number Q05788
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 69)
Name and origin of the protein
Protein name Purine nucleoside phosphorylase
Synonyms PNP
EC 2.4.2.1
Inosine phosphorylase
Gene name
Name: PNP1
OrderedLocusNames: YLR209C
ORFNames: L8167.19
From
Saccharomyces cerevisiae (Baker's yeast) [TaxID: 4932] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204511 / S288c / AB972;
PubMed=9169871 [NCBI, ExPASy, EBI, Israel, Japan]
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
Nature 387:87-90(1997).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
DOI=10.1101/gr.6037607; PubMed=17322287 [NCBI, ExPASy, EBI, Israel, Japan]
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J., Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.;
"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.";
Genome Res. 17:536-543(2007).
[3]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
DOI=10.1038/nature02046; PubMed=14562106 [NCBI, ExPASy, EBI, Israel, Japan]
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-275, AND MASS SPECTROMETRY.
DOI=10.1074/mcp.M700468-MCP200; PubMed=18407956 [NCBI, ExPASy, EBI, Israel, Japan]
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U14913; AAB67440.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY557950; AAS56276.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S48560; S48560.
RefSeq NP_013310.1; -.
3D structure databases
HSSP P55859; 1VFN. [HSSP ENTRY / PDB]
ModBase Q05788.
Protein-protein interaction databases
DIP DIP:4300N; -.
IntAct Q05788; 1.
Organism-specific databases
CYGD YLR209c; -.
SGD S000004199; PNP1.
Yeast-GFP YLR209C.
Gene expression databases
ArrayExpress Q05788; -.
GermOnline YLR209C; Saccharomyces cerevisiae.
Ontologies
GO
GO:0005622; Cellular component: intracellular (inferred by curator from SGD).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from IntAct).
GO:0004731; Molecular function: purine-nucleoside phosphorylase activity (inferred from electronic annotation from InterPro).
GO:0046115; Biological process: guanosine catabolic process (inferred from mutant phenotype from SGD).
GO:0006148; Biological process: inosine catabolic process (inferred from mutant phenotype from SGD).
GO:0019358; Biological process: nicotinate nucleotide salvage (inferred from genetic interaction from SGD).
QuickGo view.
Family and domain databases
InterPro IPR001369; Mtap_PNP.
IPR011268; PNPHPUNA_XAPA.
IPR011270; Pur_Nuc_Pase_Ino/Guo-sp.
Graphical view of domain structure.
PANTHER PTHR11904; Mtap_PNP; 1.
PTHR11904:SF9; PNPHPUNA_XAPA; 1.
Pfam PF00896; Mtap_PNP; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01700; PNPH; 1.
TIGR01697; PNPH-PUNA-XAPA; 1.
PROSITE PS01240; PNP_MTAP_2; 1.
Genome annotation databases
Ensembl YLR209C; Saccharomyces cerevisiae. [Contig view]
GeneID 850906; -.
GenomeReviews Y13138_GR; YLR209C.
KEGG sce:YLR209C; -.
NMPDR fig|4932.3.peg.4320; -.
Phylogenomic databases
HOGENOM Q05788; -.
Other
LinkHub Q05788; -.
NextBio 967302; -.
ProtoNet Q05788.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Glycosyltransferase; Phosphoprotein; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   311  311     Purine nucleoside phosphorylase. PRO_0000184538
MOD_RES   275   275        Phosphoserine. 
Sequence information
Length: 311 AA [This is the length of the unprocessed precursor] Molecular weight: 33755 Da [This is the MW of the unprocessed precursor] CRC64: 159DB9F9EC393BCA [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSDILNVSQQ REAITKAAAY ISAILEPHFK NTTNFEPPRT LIICGSGLGG ISTKLSRDNP 

        70         80         90        100        110        120 
PPVTVPYQDI PGFKKSTVPG HSGTLMFGSM NGSPVVLMNG RLHGYEGNTL FETTFPIRVL 

       130        140        150        160        170        180 
NHMGHVRNLI VTNAAGGINA KYQACDLMCI YDHLNIPGLA GQHPLRGPNL DEDGPRFLAL 

       190        200        210        220        230        240 
SDAYDLELRK LLFKKWKELK IQRPLHEGTY TFVSGPTFET RAESKMIRML GGDAVGMSTV 

       250        260        270        280        290        300 
PEVIVARHCG WRVLALSLIT NTCVVDSPAS ALDESPVPLE KGKATHAEVL ENGKIASNDV 

       310 
QNLIAAVMGE L 

Q05788 in FASTA format

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