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- FUNCTION: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin.
- FUNCTION: In addition to cross linking of extracellular matrix proteins, it may have a direct role in tumor suppression.
- CATALYTIC ACTIVITY: Peptidyl-L-lysyl-peptide + O2 + H2O = peptidyl-allysyl-peptide + NH3 + H2O2.
- COFACTOR: Copper (By similarity).
- COFACTOR: Contains 1 lysine tyrosylquinone (By similarity).
- SUBCELLULAR LOCATION: Secreted, extracellular space.
- DEVELOPMENTAL STAGE: Increases between day 8 and 16 of embryonic development, during aortic embryogenesis, in direct proportion to total protein synthesis.
- PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.
- MISCELLANEOUS: The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity).
- SIMILARITY: Belongs to the lysyl oxidase family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 420 AA [This is the length of the unprocessed precursor] |
Molecular weight: 48153 Da [This is the MW of the unprocessed precursor] |
CRC64: E0CBE81DD625F5C2 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MRCAPPGLLL AQLHACIFWS GLWPAGCQSP PAAWRQRIQW ENNGQVYSLL SQGAQYQPPR
70 80 90 100 110 120
RRQGAEPASS PVLLLRGNGS VPRAAAAAAA RPQPEPQPQA QPQPRPRSSR RQPLGRRHWF
130 140 150 160 170 180
QAGYRAPSGS ARPAPRRRPR GRRSRRRERA ERRRAAAPSG LRPGREDVMV GDDPYSPYKY
190 200 210 220 230 240
TDDNPYYNYY DTYERPRQGS RYRPGYGTGY FQYGLPDLVP DPYYIQASTY VQRMSMYNLR
250 260 270 280 290 300
CAAEENCLAS SAYRADVRDY DNRVLLRFPQ RVKNQGTSDF LPSRPRYSWE WHSCHQHYHS
310 320 330 340 350 360
MDEFSHYDLL DASSHRKVAE GHKASFCLED TSCDYGYYRR YACTAHTQGL SPGCYDTYNA
370 380 390 400 410 420
DIDCQWIDIT DVKPGNYILK VSVNPSYLVP ESDYSNNIVR CDIRYTGHHA YASGCTISPY
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Q05063 in FASTA format |
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