[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Liver; PubMed=8486656 [NCBI, ExPASy, EBI, Israel, Japan] Atta-Asafo-Adjei E., Lawton M.P., Philpot R.M.; "Cloning, sequencing, distribution, and expression in Escherichia coli of flavin-containing monooxygenase 1C1. Evidence for a third gene subfamily in rabbits."; J. Biol. Chem. 268:9681-9689(1993).
[2]	PROTEIN SEQUENCE OF 3-514. STRAIN=New Zealand white; TISSUE=Liver; DOI=10.1021/bi00178a035; PubMed=8142375 [NCBI, ExPASy, EBI, Israel, Japan] Ozols J.; "Isolation and structure of a third form of liver microsomal flavin monooxygenase."; Biochemistry 33:3751-3757(1994).

Comments

FUNCTION: In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.
CATALYTIC ACTIVITY: N,N-dimethylaniline + NADPH + O₂ = N,N-dimethylaniline N-oxide + NADP⁺ + H₂O.
COFACTOR: FAD.
SUBCELLULAR LOCATION: Microsome membrane. Endoplasmic reticulum membrane.
TISSUE SPECIFICITY: Kidney and liver.
SIMILARITY: Belongs to the FMO family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

L08449; AAA31235.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A45912; A45912.
A46677; A46677.

RefSeq

NP_001075714.1; -.

UniGene

Ocu.1864

3D structure databases

ModBase

Q04799.

Family and domain databases

InterPro

IPR000759; Adrndx_reductase.
IPR012143; dManiline_mOase.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR000960; Flavin_mOase.
IPR002257; Flavin_mOase_5.
Graphical view of domain structure.

Pfam

PF00743; FMO-like; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000332; FMO; 1.

PRINTS

PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00370; FMOXYGENASE.
PR01125; FMOXYGENASE5.

ProDom

PD000139; FAD_pyr_redox; 1.
[Domain structure / List of seq. sharing at least 1 domain]

BLOCKS

Q04799.

Genome annotation databases

GeneID

100009064; -.

Phylogenomic databases

HOVERGEN

Q04799; -.

Other

ProtoNet

Q04799.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; Direct protein sequencing; Endoplasmic reticulum; FAD; Flavoprotein; Membrane; Methylation; Microsome; Monooxygenase; NADP; Oxidoreductase; Transmembrane.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 533`	`532`	`Dimethylaniline monooxygenase [N-oxide-forming] 5.`	`PRO_0000147667`
`NP_BIND`	`10 15`	`6`	`FAD (Potential).`
`NP_BIND`	`192 197`	`6`	`NADP (By similarity).`
`MOD_RES`	`2 2`		`N-acetylalanine (By similarity).`
`MOD_RES`	`5 5`		`Omega-N-methylated arginine (By similarity).`
`VARIANT`	`132 132`	`1`	`C -> V.`
`VARIANT`	`241 241`	`1`	`S -> Q.`
`VARIANT`	`390 390`	`1`	`T -> V.`
`VARIANT`	`419 419`	`1`	`R -> F.`
`VARIANT`	`451 451`	`1`	`S -> P.`
`VARIANT`	`509 509`	`1`	`S -> L.`
`CONFLICT`	`5 5`		`R -> K (in Ref. 2; AA sequence).`
`CONFLICT`	`160 160`		`S -> K (in Ref. 2; AA sequence).`
`CONFLICT`	`306 306`		`E -> ELKE (in Ref. 2; AA sequence).`
`CONFLICT`	`512 512`		`Missing (in Ref. 2; AA sequence).`

Sequence information

Length: 533 AA [This is the length of the unprocessed precursor]

Molecular weight: 59845 Da [This is the MW of the unprocessed precursor]

CRC64: 188617ACA56E9286 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAGKRVAVIG AGASGLACIK CCLEEGLEPV CFERTDDIGG LWRFQESPDE GRASIYKSVI 

        70         80         90        100        110        120 
INTSKEMMCF SDYPIPDHFP NFMHNSQVLE YFRMYAKEFG LLKYIQFKTT VCSVKKRPDF 

       130        140        150        160        170        180 
STSGQWEVLT ECEGKKESAV FDGVLVCTGH HTSAHLPLES FPGIEKFKGQ YLHSRDYKNP 

       190        200        210        220        230        240 
EKFTGKRVIV IGIGNSGGDL AVEISHTAKQ VFLSTRRGAW IMNRVGDHGY PIDILLSSRF 

       250        260        270        280        290        300 
SQFLKKITGE TIANSFLERK MNQRFDHAMF GLKPKHRALS QHPTVNDDLP NRIISGSVKI 

       310        320        330        340        350        360 
KGNVKEFTET AAIFEDGSRE DDIDAVIFAT GYSFSFPFLE DSVKVVKNKV SLYKKVFPPN 

       370        380        390        400        410        420 
LEKPTLAIIG LIQPLGAIMP ISELQARWAT LVFKGLKTLP SQSEMMTEIS QVQEKMAKRY 

       430        440        450        460        470        480 
VESQRHTIQG DYIETMEEIA DLVGVRPNLL SLAFTDPRLA LQLLLGPCTP VHYRLQGRGK 

       490        500        510        520        530 
WDGARKTILT VEDRIRKPLM TRVTESSNSV TSMMTMGKFM LAIAFLAIAV VYF

Q04799 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools