[1]	NUCLEOTIDE SEQUENCE [MRNA]. PubMed=11537868 [NCBI, ExPASy, EBI, Israel, Japan] Williamson C.L., Slocum R.D.; "Molecular cloning and evidence for osmoregulation of the delta 1-pyrroline-5-carboxylate reductase (proC) gene in pea (Pisum sativum L.)."; Plant Physiol. 100:1464-1470(1992).

Comments

CATALYTIC ACTIVITY: L-proline + NAD(P)⁺ = 1-pyrroline-5-carboxylate + NAD(P)H.
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1 .
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the pyrroline-5-carboxylate reductase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X62842; CAA44646.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

T06477; T06477.

3D structure databases

ModBase

Q04708.

Family and domain databases

InterPro

IPR016040; NAD(P)-bd.
IPR004455; NADP_OxRdtase_F420.
IPR000304; P5CR.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PANTHER

PTHR11645; P5CR; 1.

Pfam

PF03807; F420_oxidored; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000193; Pyrrol-5-carb_rd; 1.

TIGR00112; proC; 1.

PS00521; P5CR; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Cytoplasm; NADP; Oxidoreductase; Proline biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 273`	`273`		`Pyrroline-5-carboxylate reductase.`	`PRO_0000187324`

Sequence information

Length: 273 AA [This is the length of the unprocessed precursor]

Molecular weight: 28238 Da [This is the MW of the unprocessed precursor]

CRC64: D719F52935966588 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEILPILSDS YTLGFIGAGK MAESIAKGAS RSGVLPSSRI VTAHSNPSRR AAFESIGITV 

        70         80         90        100        110        120 
LSSNDDVVRA SNVVVFSVKP QLVKDVVLKL KPLLTKDKLL VSVAAGIKLK DLQEWAGHER 

       130        140        150        160        170        180 
FIRVMPNTPA AVGQAASVMS LGGAATEEDA NLISQLFGSI GKIWKADDKF FDAITGLSGS 

       190        200        210        220        230        240 
GPAYIYLAIE ALADGGVAAG LPRDLALSLA SQTVLGAASM ATLSGKHPGQ LKDDVTSPGG 

       250        260        270 
TTIAGVHELE KGGFRGTLMN AVVAAAKRSR ELS

Q04708 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools