NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=1535523 [NCBI, ExPASy, EBI, Israel, Japan]
Choi G.H., Larson T.G., Nuss D.L.;
"Molecular analysis of the laccase gene from the chestnut blight fungus and selective suppression of its expression in an isogenic hypovirulent strain.";
Mol. Plant Microbe Interact. 5:119-128(1992).

Comments

FUNCTION: Lignin degradation and detoxification of lignin-derived products (By similarity).
CATALYTIC ACTIVITY: 4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.
COFACTOR: Binds 4 copper ions per monomer (By similarity).
SUBCELLULAR LOCATION: Secreted (Potential).
SIMILARITY: Belongs to the multicopper oxidase family.
SIMILARITY: Contains 3 plastocyanin-like domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M73257; AAA33105.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
S38903; AAA09235.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q9Y780; 1HFU. [HSSP ENTRY / PDB]

ModBase

Q03966.

Family and domain databases

InterPro

IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.420; Cupredoxin; 3.

Pfam

PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.

PROSITE

PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Repeat; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 20`	`20`	`Potential.`
`CHAIN`	`21 591`	`571`	`Laccase.`	`PRO_0000002920`
`DOMAIN`	`66 189`	`124`	`Plastocyanin-like 1.`
`DOMAIN`	`198 356`	`159`	`Plastocyanin-like 2.`
`DOMAIN`	`416 551`	`136`	`Plastocyanin-like 3.`
`METAL`	`126 126`		`Copper 1; type 2 (By similarity).`
`METAL`	`128 128`		`Copper 2; type 3 (By similarity).`
`METAL`	`171 171`		`Copper 2; type 3 (By similarity).`
`METAL`	`173 173`		`Copper 3; type 3 (By similarity).`
`METAL`	`463 463`		`Copper 4; type 1 (By similarity).`
`METAL`	`466 466`		`Copper 1; type 2 (By similarity).`
`METAL`	`468 468`		`Copper 3; type 3 (By similarity).`
`METAL`	`533 533`		`Copper 3; type 3 (By similarity).`
`METAL`	`534 534`		`Copper 4; type 1 (By similarity).`
`METAL`	`535 535`		`Copper 2; type 3 (By similarity).`
`METAL`	`539 539`		`Copper 4; type 1 (By similarity).`
`CARBOHYD`	`121 121`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`234 234`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`242 242`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`265 265`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`323 323`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`407 407`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`425 425`		`N-linked (GlcNAc...) (Potential).`

Sequence information

Length: 591 AA [This is the length of the unprocessed precursor]

Molecular weight: 64696 Da [This is the MW of the unprocessed precursor]

CRC64: B2F44CB2AAD77701 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPSFFRALFS GLIASQLSWA APSLLHPLEP RQQPNCNTAS NRACWISGSY DITTDYEVKT 

        70         80         90        100        110        120 
PLTGVVRQYD LTLTQAENWL GPDGVVKEDV MLVNGNILGP VIHAQWGDTI SVTVTNNLKY 

       130        140        150        160        170        180 
NGTTIHWHGI RQLNTNLQDG VNGITECPIP PNGGSKTYTF IAHQYGTSWY HSHFSAQYGN 

       190        200        210        220        230        240 
GIVGAIQIDG PASLPYDIDL GPLVLSDYYY KTADELVVYT QSNAPPASDN VLFNGTNINP 

       250        260        270        280        290        300 
ANTTQGQYKT ITLTPGKRHR LRIINTSVEN NFQVSIVGHS MTVIESDFVP VDSFTTDSLF 

       310        320        330        340        350        360 
VGIGQRYDVT IDASQATDNY WMNVTFGGGG FCGKSNNPYP AAIIHYNGAS NSHPTNKGVA 

       370        380        390        400        410        420 
PADHECLDLL NLVPVVPRSI PTSGFVAASD NTLDVQLSTT TRKWTINGST LDVDWGHPIT 

       430        440        450        460        470        480 
QYVINKSTAW PSTDNVWLVE EANQWAYWLI ENDPTATGNA LPHPIHLHGH DFVVLGRSPN 

       490        500        510        520        530        540 
VSPTAQTPYT FTSSDVSSLN GNNPIRRDVV MLPPKGWLLI AFQTTNPGAW LMHCHIAWHV 

       550        560        570        580        590 
SAGLGNTFLE QPSAFVAGLN TNDVNQLNSQ CKSWNAYYPS KDIFKQDDSG V

Q03966 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools