[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=Sprague-Dawley; TISSUE=Lung; PubMed=1370487 [NCBI, ExPASy, EBI, Israel, Japan] Haefliger J.-A., Bruzzone R., Jenkins N.A., Gilbert D.J., Copeland N.G., Paul D.L.; "Four novel members of the connexin family of gap junction proteins. Molecular cloning, expression, and chromosome mapping."; J. Biol. Chem. 267:2057-2064(1992).
[2]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. TISSUE=Kidney, and Ovary; DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
SUBUNIT: A connexon is composed of a hexamer of connexins.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.
TISSUE SPECIFICITY: Highly expressed in lung.
SIMILARITY: Belongs to the connexin family. Alpha-type (group II) subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M76532; AAA40999.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC078837; AAH78837.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC086576; AAH86576.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

B42053; B42053.

NP_067686.1; -.

3D structure databases

ModBase

Q03190.

Organism-specific databases

RGD

2691; Gja4.

Gene expression databases

ArrayExpress

Q03190; -.

GermOnline

ENSRNOG00000014357; Rattus norvegicus.

Ontologies

GO:0016021;	Cellular component: integral to membrane (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR000500; Connexin.
IPR002263; Connexin37.
IPR013092; Connexin_N.
Graphical view of domain structure.

PANTHER

PTHR11984; Connexin; 1.
PTHR11984:SF17; Connexin37; 1.

Pfam

PF00029; Connexin; 1.
Pfam graphical view of domain structure.

SMART

SM00037; CNX; 1.
SMART graphical view of domain structure.

PROSITE

PS00407; CONNEXINS_1; 1.
PS00408; CONNEXINS_2; 1.

Genome annotation databases

Ensembl

ENSRNOG00000014357; Rattus norvegicus. [Contig view]

GeneID

25655; -.

KEGG

rno:25655; -.

Phylogenomic databases

HOVERGEN

Q03190; -.

Other

NextBio

607545; -.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell junction; Cell membrane; Gap junction; Membrane; Transmembrane.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 333`	`332`	`Gap junction alpha-4 protein.`	`PRO_0000057817`
`TOPO_DOM`	`2 20`	`19`	`Cytoplasmic (Potential).`
`TRANSMEM`	`21 40`	`20`	`Potential.`
`TOPO_DOM`	`41 76`	`36`	`Extracellular (Potential).`
`TRANSMEM`	`77 99`	`23`	`Potential.`
`TOPO_DOM`	`100 148`	`49`	`Cytoplasmic (Potential).`
`TRANSMEM`	`149 171`	`23`	`Potential.`
`TOPO_DOM`	`172 208`	`37`	`Extracellular (Potential).`
`TRANSMEM`	`209 231`	`23`	`Potential.`
`TOPO_DOM`	`232 333`	`102`	`Cytoplasmic (Potential).`

Sequence information

Length: 333 AA [This is the length of the unprocessed precursor]

Molecular weight: 37556 Da [This is the MW of the unprocessed precursor]

CRC64: ABAF5D9462CBBC97 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGDWGFLEKL LDQVQEHSTV VGKIWLTVLF IFRILILGLA GESVWGDEQS DFECNTAQPG 

        70         80         90        100        110        120 
CTNVCYDQAF PISHIRYWVL QFLFVSTPTL IYLGHVIYLS RREERLRQKE GELRALPSKD 

       130        140        150        160        170        180 
PHVERALAAI EHQMAKISVA EDGRLRIRGA LMGTYVISVL CKSVLEAGFL YGQWRLYGWT 

       190        200        210        220        230        240 
MEPVFVCQRA PCPHVVDCYV SRPTEKTIFI IFMLVVGVIS LVLNLLELVH LLCRCVSREI 

       250        260        270        280        290        300 
KARRDHDTRP AQGSASDPYP EQVFFYLPMG EGPSSPPCPT YNGLSSTEQN WANLTTEERL 

       310        320        330 
TSTRPPPFVN AAPQGGQKSS SRPNSSASKK QYV

Q03190 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools