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UniProtKB/Swiss-Prot entry Q02Z38


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_LACLS
Primary accession number Q02Z38
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on November 14, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 15)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: LACR_1256
From
Lactococcus lactis subsp. cremoris (strain SK11) [TaxID: 272622] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0607117103; PubMed=17030793 [NCBI, ExPASy, EBI, Israel, Japan]
Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
"Comparative genomics of the lactic acid bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000425; ABJ72784.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_809206.1; -.
3D structure databases
SMR Q02Z38; 4-324.
ModBase Q02Z38.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q02Z38.
Genome annotation databases
GeneID 4433255; -.
GenomeReviews CP000425_GR; LACR_1256.
KEGG llc:LACR_1256; -.
CMR Q02Z38; LACR_1256.
Other
ProtoNet Q02Z38.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   329  329     GMP reductase. PRO_0000294276
NP_BIND   207   230  24     NADP (Potential). 
ACT_SITE   178   178        Thioimidate intermediate (By similarity). 
Sequence information
Length: 329 AA [This is the length of the unprocessed precursor] Molecular weight: 35828 Da [This is the MW of the unprocessed precursor] CRC64: D11BBDD5203C4633 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNNLNSVFDY EDIQLIPNKC VINSRSEADT SVKLGNYTFK LPVVPANMQT IIDDKIAEML 

        70         80         90        100        110        120 
AKEGYFYIMH RFEAENRAAF IKKMHKDGLI ASISVGVKAD EHAFIREISA EALIPEFITI 

       130        140        150        160        170        180 
DIAHGHADSV IKTIQLIKRL MPQTFVIAGN VGTPEAVREL ENAGADATKV GIGPGKVCIT 

       190        200        210        220        230        240 
KVKTGFGTGG WQLAAVKWCA KAASKPVIAD GGIRTHGDIA KSIRMGATMV MVGSLFAAHE 

       250        260        270        280        290        300 
ESPGQTVERD GQLFKEYFGS ASEYQKGEHK NVEGKKILLP HKGSLKDTLK EMEEDLQSSI 

       310        320 
SYAGGRDLSA LTKVDYVVVK NSIWNGDAI 

Q02Z38 in FASTA format

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