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UniProtKB/Swiss-Prot entry Q02418


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MTLD_STRMU
Primary accession number Q02418
Secondary accession numbers None
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on November 28, 2002 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 55)
Name and origin of the protein
Protein name Mannitol-1-phosphate 5-dehydrogenase
Synonym EC 1.1.1.17
Gene name
Name: mtlD
OrderedLocusNames: SMU_1182
From
Streptococcus mutans [TaxID: 1309] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Streptococcus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 700611 / UA130 / Serotype c;
PubMed=1322373 [NCBI, ExPASy, EBI, Israel, Japan]
Honeyman A.L., Curtiss R. III;
"Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system.";
Infect. Immun. 60:3369-3375(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 700610 / UA159 / Serotype c;
DOI=10.1073/pnas.172501299; PubMed=12397186 [NCBI, ExPASy, EBI, Israel, Japan]
Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B., Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S., Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
"Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen.";
Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF210133; AAA26942.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014133; AAN58872.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR C44798; C44798.
RefSeq NP_721566.1; -.
3D structure databases
ModBase Q02418.
Enzyme and pathway databases
BioCyc MetaCyc:MON-13098; -.
SMUT210007:SMU_1182-MON; -.
Ontologies
GO
GO:0008926; Molecular function: mannitol-1-phosphate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00196; -; 1.
PBIL [Tree]
InterPro IPR013328; DHase_multihelical.
IPR013118; Mannitol_DHase_C.
IPR000669; Mannitol_DHase_core.
IPR013131; Mannitol_DHase_N.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
G3DSA:1.10.1040.10; Opine_DH; 1.
Pfam PF01232; Mannitol_dh; 1.
PF08125; Mannitol_dh_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00084; MTLDHDRGNASE.
PROSITE PS00974; MANNITOL_DHGENASE; 1.
BLOCKS Q02418.
Genome annotation databases
GeneID 1028490; -.
GenomeReviews AE014133_GR; SMU_1182.
KEGG smu:SMU.1182; -.
NMPDR fig|210007.1.peg.1079; -.
Phylogenomic databases
HOGENOM Q02418; -.
Genome annotation databases
CMR Q02418; SMU_1182.
Other
ProtoNet Q02418.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   382  382     Mannitol-1-phosphate 5-dehydrogenase. PRO_0000170725
NP_BIND   4    15  12     NAD (By similarity). 
CONFLICT   170   170        E -> K (in Ref. 1; AAA26942). 
Sequence information
Length: 382 AA [This is the length of the unprocessed precursor] Molecular weight: 42972 Da [This is the MW of the unprocessed precursor] CRC64: B2C1F81856A1CA9D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MKKAVHFGAG NIGRGFIGQI LFENGFAIDF VDVNDKIINA LNERHSYDIE IAEDGKRHIT 

        70         80         90        100        110        120 
VSNVAGINNK ENPQAVIDAV AETELITTAI GPNILPFIAQ LIAKGIEKRR ESQNQTPLDI 

       130        140        150        160        170        180 
IACENMIGGS AFLWQEVQKY LSADGLAFAK DYIGFPNAAV DRIVPAQVHE DPLFVVVEPF 

       190        200        210        220        230        240 
SEWVVETAAM KNPDLKLSSV HYEENLEPFI ERKLFSVNSG HATTAYTGAY FGAKTVLEAL 

       250        260        270        280        290        300 
KDQQVKEQVK AVLGEIRQLL MAKWQFKEND LKVYHDIIIS RFENPYIVDD VTRVARTPIR 

       310        320        330        340        350        360 
KLGYDERFIR PIRELKDRGL SYEYLLQTVA YVFHYKDSND EQSVQLKLLL QEKSLKAVVK 

       370        380 
EVTGLTDAAL IEEIVTSVES LD 

Q02418 in FASTA format

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