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UniProtKB/Swiss-Prot entry Q02338

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BDH_HUMAN
Primary accession number Q02338
Secondary accession numbers Q96ET1 Q9BRZ4
Integrated into Swiss-Prot on July 1, 1993
Sequence was last modified on November 15, 2002 (Sequence version 3)
Annotations were last modified on    September 23, 2008 (Entry version 79)
Name and origin of the protein
Protein name D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms BDH
EC 1.1.1.30
3-hydroxybutyrate dehydrogenase
Gene name
Name: BDH1
Synonyms: BDH
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Heart;
PubMed=1639787 [NCBI, ExPASy, EBI, Israel, Japan]
Marks A.R., McIntyre J.O., Duncan T.M., Erdjument-Bromage H., Tempst P., Fleischer S.;
"Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart.";
J. Biol. Chem. 267:15459-15463(1992).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, and Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M93107; AAA58352.1; ALT_FRAME; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC005844; AAH05844.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC011964; AAH11964.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC019317; AAH19317.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A42845; A42845.
RefSeq NP_004042.1; -.
NP_976059.1; -.
NP_976060.1; -.
UniGene Hs.274539
3D structure databases
HSSP P14061; 1FDS. [HSSP ENTRY / PDB]
ModBase Q02338.
Enzyme and pathway databases
Reactome REACT_602; Lipid and lipoprotein metabolism.
Organism-specific databases
HGNC HGNC:1027; BDH1.
GenAtlas BDH1.
MIM 603063; gene. [NCBI / EBI]
PharmGKB PA25331; -.
GeneCards Q02338.
Gene expression databases
ArrayExpress Q02338; -.
CleanEx HS_BDH1; -.
GermOnline ENSG00000161267; Homo sapiens.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (non-traceable author statement from UniProtKB).
GO:0003858; Molecular function: 3-hydroxybutyrate dehydrogenase activity (traceable author statement from UniProtKB).
GO:0008152; Biological process: metabolic process (traceable author statement from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS Q02338.
Proteomic databases
PeptideAtlas Q02338; -.
Genome annotation databases
Ensembl ENSG00000161267; Homo sapiens. [Contig view]
GeneID 622; -.
KEGG hsa:622; -.
Phylogenomic databases
HOGENOM Q02338; -.
HOVERGEN Q02338; -.
Other
DrugBank DB00157; NADH.
SOURCE BDH1; Homo sapiens.
ProtoNet Q02338.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Allosteric enzyme; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    46  46     Mitochondrion (By similarity). 
CHAIN   47   343  297     D-beta-hydroxybutyrate dehydrogenase, mitochondrial. PRO_0000031960
NP_BIND   59    83  25     NAD (By similarity). 
ACT_SITE   208   208        Proton acceptor (By similarity). 
BINDING   195   195        Substrate (By similarity). 
MOD_RES   132   132        N6-acetyllysine (By similarity). 
MOD_RES   275   275        N6-acetyllysine (By similarity). 
CONFLICT   70    70        S -> A (in Ref. 2; AAH11964). 
CONFLICT   115   116        CS -> FR (in Ref. 1; AAA58352). 
CONFLICT   249   249        S -> N (in Ref. 1; AAA58352). 
Sequence information
Length: 343 AA [This is the length of the unprocessed precursor] Molecular weight: 38157 Da [This is the MW of the unprocessed precursor] CRC64: B8AA1148111ACA8F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLATRLSRPL SRLPGKTLSA CDRENGARRP LLLGSTSFIP IGRRTYASAA EPVGSKAVLV 

        70         80         90        100        110        120 
TGCDSGFGFS LAKHLHSKGF LVFAGCLMKD KGHDGVKELD SLNSDRLRTV QLNVCSSEEV 

       130        140        150        160        170        180 
EKVVEIVRSS LKDPEKGMWG LVNNAGISTF GEVEFTSLET YKQVAEVNLW GTVRMTKSFL 

       190        200        210        220        230        240 
PLIRRAKGRV VNISSMLGRM ANPARSPYCI TKFGVEAFSD CLRYEMYPLG VKVSVVEPGN 

       250        260        270        280        290        300 
FIAATSLYSP ESIQAIAKKM WEELPEVVRK DYGKKYFDEK IAKMETYCSS GSTDTSPVID 

       310        320        330        340 
AVTHALTATT PYTRYHPMDY YWWLRMQIMT HLPGAISDMI YIR
Q02338 in FASTA format

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