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UniProtKB/Swiss-Prot entry Q02337

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name BDH_BOVIN
Primary accession number Q02337
Secondary accession number Q3ZBX3
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on July 25, 2006 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 52)
Name and origin of the protein
Protein name D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Precursor]
Synonyms BDH
EC 1.1.1.30
3-hydroxybutyrate dehydrogenase
Gene name
Name: BDH1
Synonyms: BDH
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Heart ventricle;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2]
 PROTEIN SEQUENCE OF 47-89; 138-174; 213-231; 233-259; 285-322 AND 331-344.
TISSUE=Heart;
PubMed=1639787 [NCBI, ExPASy, EBI, Israel, Japan]
Marks A.R., McIntyre J.O., Duncan T.M., Erdjument-Bromage H., Tempst P., Fleischer S.;
"Molecular cloning and characterization of (R)-3-hydroxybutyrate dehydrogenase from human heart.";
J. Biol. Chem. 267:15459-15463(1992).
[3]
 PROTEIN SEQUENCE OF 163-174 AND 285-301.
TISSUE=Heart;
PubMed=3527172 [NCBI, ExPASy, EBI, Israel, Japan]
Prasad P.V., Hatefi Y.;
"Amino acid sequences of two tryptic peptides from D(-)-beta-hydroxybutyrate dehydrogenase radiolabeled at essential carboxyl and sulfhydryl groups.";
Biochem. Int. 12:941-949(1986).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC103051; AAI03052.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR B42845; B42845.
RefSeq NP_001029772.1; -.
UniGene Bt.49607
3D structure databases
ModBase Q02337.
Ontologies
GO
GO:0005759; Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002198; DHase_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR19410; ADH_short_C2; 1.
Pfam PF00106; adh_short; 1.
Pfam graphical view of domain structure.
PRINTS PR00081; GDHRDH.
PR00080; SDRFAMILY.
PROSITE PS00061; ADH_SHORT; 1.
BLOCKS Q02337.
Genome annotation databases
Ensembl ENSBTAG00000000448; Bos taurus. [Contig view]
GeneID 534090; -.
KEGG bta:534090; -.
Phylogenomic databases
HOVERGEN Q02337; -.
Other
ProtoNet Q02337.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Allosteric enzyme; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    46  46     Mitochondrion. 
CHAIN   47   344  298     D-beta-hydroxybutyrate dehydrogenase, mitochondrial. PRO_0000054526
NP_BIND   59    83  25     NAD (By similarity). 
ACT_SITE   208   208        Proton acceptor (By similarity). 
BINDING   195   195        Substrate (By similarity). 
MOD_RES   276   276        N6-acetyllysine (By similarity). 
Sequence information
Length: 344 AA [This is the length of the unprocessed precursor] Molecular weight: 38391 Da [This is the MW of the unprocessed precursor] CRC64: C8C7AC75FA09880E [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLTARLSRPL SQLPRKTLNF SDRENGTRGS LLLYSAPFVP VGRRTYAASV DPVGSKAVLI 

        70         80         90        100        110        120 
TGCDSGFGFS LAKHLHSEGF LVFAGCLMKD KGSDGVKELD SMKSDRLRTV QLNVCKSEEV 

       130        140        150        160        170        180 
DKAAEVIRSS LEDPEKGLWG LVNNAGISTF GDVEFTSMET YKEVAEVNLW GTVRVTKAFL 

       190        200        210        220        230        240 
PLIRRAKGRV VNISSMMGRM ANVARSPYCI TKFGVEAFSD CLRYEMHPLG VKVSVVEPGN 

       250        260        270        280        290        300 
FIAATSLYGG TERIQAIANK MWEELPEVVR QDYGRKYFDE KVARMESYCT SGSTDTSPVI 

       310        320        330        340 
KAVTHALTAT TPYTRYHPMD YYWWLRMQIM THFPGAISDR IYIH
Q02337 in FASTA format

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