NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=RS22;
DOI=10.1007/s002940050061; PubMed=8598061 [NCBI, ExPASy, EBI, Israel, Japan]
Wahleithner J.A., Xu F., Brown K.M., Brown S.H., Golightly E.J., Halkier T., Kauppinen S., Pederson A., Schneider P.;
"The identification and characterization of four laccases from the plant pathogenic fungus Rhizoctonia solani.";
Curr. Genet. 29:395-403(1996).

Comments

FUNCTION: Lignin degradation and detoxification of lignin-derived products (Probable).
CATALYTIC ACTIVITY: 4 benzenediol + O₂ = 4 benzosemiquinone + 2 H₂O.
COFACTOR: Binds 4 copper ions per monomer (By similarity).
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: In mycelia, at a lower level than LCC4.
SIMILARITY: Belongs to the multicopper oxidase family.
SIMILARITY: Contains 3 plastocyanin-like domains.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z54215; CAA90942.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S68119; S68119.

3D structure databases

HSSP

Q9Y780; 1HFU. [HSSP ENTRY / PDB]

ModBase

Q02079.

Ontologies

GO:0008471;	Molecular function: laccase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR001117; Cu-oxidase.
IPR011706; Cu-oxidase_2.
IPR011707; Cu-oxidase_3.
IPR002355; Cu_oxidase_Cu_BS.
IPR008972; Cupredoxin.
Graphical view of domain structure.

Gene3D

G3DSA:2.60.40.420; Cupredoxin; 3.

Pfam

PF00394; Cu-oxidase; 1.
PF07731; Cu-oxidase_2; 1.
PF07732; Cu-oxidase_3; 1.
Pfam graphical view of domain structure.

PROSITE

PS00079; MULTICOPPER_OXIDASE1; 1.
PS00080; MULTICOPPER_OXIDASE2; FALSE_NEG.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Copper; Glycoprotein; Lignin degradation; Metal-binding; Oxidoreductase; Polymorphism; Repeat; Secreted; Signal.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 18`	`18`	`Potential.`
`CHAIN`	`19 572`	`554`	`Laccase-3.`	`PRO_0000002937`
`DOMAIN`	`21 145`	`125`	`Plastocyanin-like 1.`
`DOMAIN`	`157 304`	`148`	`Plastocyanin-like 2.`
`DOMAIN`	`422 540`	`119`	`Plastocyanin-like 3.`
`METAL`	`82 82`		`Copper 1 (type 2) (By similarity).`
`METAL`	`84 84`		`Copper 2 (type 3) (By similarity).`
`METAL`	`127 127`		`Copper 2 (type 3) (By similarity).`
`METAL`	`129 129`		`Copper 3 (type 3) (By similarity).`
`METAL`	`470 470`		`Copper 4 (type 1) (By similarity).`
`METAL`	`473 473`		`Copper 1 (type 2) (By similarity).`
`METAL`	`475 475`		`Copper 3 (type 3) (By similarity).`
`METAL`	`522 522`		`Copper 3 (type 3) (By similarity).`
`METAL`	`523 523`		`Copper 4 (type 1) (By similarity).`
`METAL`	`524 524`		`Copper 2 (type 3) (By similarity).`
`METAL`	`528 528`		`Copper 4 (type 1) (By similarity).`
`CARBOHYD`	`182 182`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`228 228`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`294 294`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`367 367`		`N-linked (GlcNAc...) (Potential).`
`CARBOHYD`	`405 405`		`N-linked (GlcNAc...) (Potential).`
`VARIANT`	`159 159`	`1`	`D -> N.`
`VARIANT`	`359 359`	`1`	`R -> H.`
`VARIANT`	`418 418`	`1`	`H -> Y.`
`VARIANT`	`448 448`	`1`	`I -> V.`

Sequence information

Length: 572 AA [This is the length of the unprocessed precursor]

Molecular weight: 63747 Da [This is the MW of the unprocessed precursor]

CRC64: DF1E2AF9FF108CE4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MARTTFLVSV SLFVSAVLAR TVEYNLKISN GKIAPDGVER DATLVNGGYP GPLIFANKGD 

        70         80         90        100        110        120 
TLKVKVQNKL TNPDMYRTTS IHWHGLLQHR NADDDGPAFV TQCPIVPQAS YTYTMPLGDQ 

       130        140        150        160        170        180 
TGTYWYHSHL SSQYVDGLRG PLVIYDPKDP HRRLYDIDDE KTVLIIGDWY HTSSKAILAT 

       190        200        210        220        230        240 
GNITLQQPDS ATINGKGRFD PDNTPANPNT LYTLKVKRGK RYRLRVINSS AIASFRMSIQ 

       250        260        270        280        290        300 
GHKMTVIAAD GVSTKPYQVD SFDILAGQRI DAVVEANQEP DTYWINAPLT NVANKTAQAL 

       310        320        330        340        350        360 
LIYEDDRRPY HPPKGPYRKW SVSEAIIKYW KHKHGRGLLS GHGGLKARMM EGSLHLHGRR 

       370        380        390        400        410        420 
DIVKRQNETT TVVMDETKLV PLEHPGAACG SKPADLVIDL TFGVNFTTGH WMINGIPHKS 

       430        440        450        460        470        480 
PDMPTLLKIL TDTDGVTESD FTQPEHTIIL PKNKCVEFNI KGNSGLGIVH PIHLHGHTFD 

       490        500        510        520        530        540 
VVQFGNNPPN YVNPPRRDVV GATDEGVRFQ FKTDNPGPWF LHCHIDWHLE EGFAMVFAEA 

       550        560        570 
PEAIKGGPKS VPVDRQWKDL CRKYGSLPAG FL

Q02079 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools