[1]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=MHOM/IR/83/Lt252 / CC-1;
PubMed=1339441 [NCBI, ExPASy, EBI, Israel, Japan]
Callahan H.L.,
Beverley S.M.;
"A member of the aldoketo reductase family confers methotrexate resistance in Leishmania.";
J. Biol. Chem. 267:24165-24168(1992).
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[2]
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SEQUENCE REVISION TO 162-171.
Callahan H.L.,
Beverley S.M.;
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MHOM/IL/81/Friedlin;
DOI=10.1126/science.1112680; PubMed=16020728 [NCBI, ExPASy, EBI, Israel, Japan]
Ivens A.C.,
Peacock C.S.,
Worthey E.A.,
Murphy L.,
Aggarwal G.,
Berriman M.,
Sisk E.,
Rajandream M.A.,
Adlem E.,
Aert R.,
Anupama A.,
Apostolou Z.,
Attipoe P.,
Bason N.,
Bauser C.,
Beck A.,
Beverley S.M.,
Bianchettin G.,
Borzym K., ![]()
Bothe G.,
Bruschi C.V.,
Collins M.,
Cadag E.,
Ciarloni L.,
Clayton C.,
Coulson R.M.R.,
Cronin A.,
Cruz A.K.,
Davies R.M.,
De Gaudenzi J.,
Dobson D.E.,
Duesterhoeft A.,
Fazelina G.,
Fosker N.,
Frasch A.C.,
Fraser A.,
Fuchs M.,
Gabel C.,
Goble A.,
Goffeau A.,
Harris D.,
Hertz-Fowler C.,
Hilbert H.,
Horn D.,
Huang Y.,
Klages S.,
Knights A.,
Kube M.,
Larke N.,
Litvin L.,
Lord A.,
Louie T.,
Marra M.,
Masuy D.,
Matthews K.,
Michaeli S.,
Mottram J.C.,
Mueller-Auer S.,
Munden H.,
Nelson S.,
Norbertczak H.,
Oliver K.,
O'neil S.,
Pentony M.,
Pohl T.M.,
Price C.,
Purnelle B.,
Quail M.A.,
Rabbinowitsch E.,
Reinhardt R.,
Rieger M.,
Rinta J.,
Robben J.,
Robertson L.,
Ruiz J.C.,
Rutter S.,
Saunders D.,
Schaefer M.,
Schein J.,
Schwartz D.C.,
Seeger K.,
Seyler A.,
Sharp S.,
Shin H.,
Sivam D.,
Squares R.,
Squares S.,
Tosato V.,
Vogt C.,
Volckaert G.,
Wambutt R.,
Warren T.,
Wedler H.,
Woodward J.,
Zhou S.,
Zimmermann W.,
Smith D.F.,
Blackwell J.M.,
Stuart K.D.,
Barrell B.G.,
Myler P.J.;
"The genome of the kinetoplastid parasite, Leishmania major.";
Science 309:436-442(2005).
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[4]
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FUNCTION.
PubMed=7972081 [NCBI, ExPASy, EBI, Israel, Japan]
Bello A.R.,
Nare B.,
Freedman D.,
Hardy L.W.,
Beverley S.M.;
"PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.";
Proc. Natl. Acad. Sci. U.S.A. 91:11442-11446(1994).
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[5]
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SUBUNIT.
STRAIN=MHOM/IR/83/Lt252;
DOI=10.1074/jbc.272.21.13883; PubMed=9153248 [NCBI, ExPASy, EBI, Israel, Japan]
Nare B.,
Hardy L.W.,
Beverley S.M.;
"The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major.";
J. Biol. Chem. 272:13883-13891(1997).
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[6]
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X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH NADP AND SUBSTRATE.
DOI=10.1038/88584; PubMed=11373620 [NCBI, ExPASy, EBI, Israel, Japan]
Gourley D.G.,
Schuettelkopf A.W.,
Leonard G.A.,
Luba J.,
Hardy L.W.,
Beverley S.M.,
Hunter W.N.;
"Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites.";
Nat. Struct. Biol. 8:521-525(2001).
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[7]
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PATHWAY.
DOI=10.1021/bi972693a; PubMed=9521731 [NCBI, ExPASy, EBI, Israel, Japan]
Luba J.,
Nare B.,
Liang P.-H.,
Anderson K.S.,
Beverley S.M.,
Hardy L.W.;
"Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence.";
Biochemistry 37:4093-4104(1998).
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