[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; PubMed=8612589 [NCBI, ExPASy, EBI, Israel, Japan] Ballario P., Vittorioso P., Magrelli A., Talora C., Cabibbo A., Macino G.; "White collar-1, a central regulator of blue light responses in Neurospora, is a zinc finger protein."; EMBO J. 15:1650-1657(1996).
[2]	SEQUENCE REVISION TO C-TERMINUS. Ballario P.; Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987; DOI=10.1038/nature01554; PubMed=12712197 [NCBI, ExPASy, EBI, Israel, Japan] Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D., Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B., Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M., Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M., Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U., Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D., Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S., Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D., Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S., Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A., DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R., Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R., Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I., Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.; "The genome sequence of the filamentous fungus Neurospora crassa."; Nature 422:859-868(2003).

Comments

FUNCTION: May function as a transcription factor involved in light regulation. Binds and affects blue light regulation of the AL-3 gene. WC1 and WC2 proteins interact via homologous PAS domains, bind to promoters of light regulated genes such as FRQ, and activate transcription.
SUBUNIT: Heterodimer of WC1 and WC2 (Potential).
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: By blue light.
DOMAIN: The glutamine-rich domain might function in activating gene expression.
PTM: FMN binds covalently to cysteine after exposure to blue light and is reversed in the dark (By similarity).
SIMILARITY: Contains 1 GATA-type zinc finger.
SIMILARITY: Contains 2 PAC (PAS-associated C-terminal) domains.
SIMILARITY: Contains 3 PAS (PER-ARNT-SIM) domains.
SEQUENCE CAUTION:
- Sequence=EAA30541.2; Type=Erroneous gene model prediction;

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

X94300; CAA63964.2; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AABX02000010; EAA30541.2; ALT_SEQ; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

P17679; 1GNF. [HSSP ENTRY / PDB]

ModBase

Q01371.

Protein-protein interaction databases

DIP

DIP:1155N; -.

Ontologies

GO:0005634;	Cellular component: nucleus (inferred from electronic annotation from UniProtKB-SubCell).
GO:0009881;	Molecular function: photoreceptor activity (inferred from electronic annotation from UniProtKB-KW).
GO:0043565;	Molecular function: sequence-specific DNA binding (inferred from electronic annotation from InterPro).
GO:0003700;	Molecular function: transcription factor activity (inferred from electronic annotation from InterPro).
GO:0008270;	Molecular function: zinc ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0018298;	Biological process: protein-chromophore linkage (inferred from electronic annotation from UniProtKB-KW).
GO:0006355;	Biological process: regulation of transcription, DNA-dependent (inferred from electronic annotation from UniProtKB-KW).
GO:0050896;	Biological process: response to stimulus (inferred from electronic annotation from UniProtKB-KW).
GO:0007165;	Biological process: signal transduction (inferred from electronic annotation from InterPro).
GO:0006350;	Biological process: transcription (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

InterPro

IPR001610; PAC.
IPR000014; PAS.
IPR013655; PAS_fold_3.
IPR000679; Znf_GATA.
IPR013088; Znf_NHR/GATA.
Graphical view of domain structure.

Gene3D

G3DSA:3.30.50.10; Znf_NHR/GATA; 1.

Pfam

PF00320; GATA; 1.
PF08447; PAS_3; 1.
Pfam graphical view of domain structure.

SMART

SM00086; PAC; 2.
SM00091; PAS; 3.
SM00401; ZnF_GATA; 1.
SMART graphical view of domain structure.

TIGRFAMs

TIGR00229; sensory_box; 1.

PROSITE

PS00344; GATA_ZN_FINGER_1; 1.
PS50114; GATA_ZN_FINGER_2; 1.
PS50113; PAC; FALSE_NEG.
PS50112; PAS; 3.
PROSITE graphical view of domain structure (profiles).

Other

ProtoNet

Q01371.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Activator; Chromophore; Complete proteome; DNA-binding; Flavoprotein; FMN; Metal-binding; Nucleus; Photoreceptor protein; Receptor; Repeat; Sensory transduction; Transcription; Transcription regulation; Zinc; Zinc-finger.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 1167`	`1167`	`White collar 1 protein.`	`PRO_0000083489`
`DOMAIN`	`381 452`	`72`	`PAS 1.`
`DOMAIN`	`469 508`	`40`	`PAC 1.`
`DOMAIN`	`574 644`	`71`	`PAS 2.`
`DOMAIN`	`650 691`	`42`	`PAC 2.`
`DOMAIN`	`693 763`	`71`	`PAS 3.`
`ZN_FING`	`934 959`	`26`	`GATA-type.`
`COMPBIAS`	`16 61`	`46`	`Gln-rich.`
`COMPBIAS`	`21 57`	`37`	`Poly-Gln.`
`COMPBIAS`	`329 333`	`5`	`Poly-Pro.`
`MOD_RES`	`428 428`		`S-4a-FMN cysteine (By similarity).`
`CONFLICT`	`1167 1167`		`V -> Q (in Ref. 3; EAA30541).`

Sequence information

Length: 1167 AA [This is the length of the unprocessed precursor]

Molecular weight: 127454 Da [This is the MW of the unprocessed precursor]

CRC64: 6489D04DAB50EE38 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNNNYYGSPL SPEELQHQMH QHQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ HQHQQQQKTN 

        70         80         90        100        110        120 
QHRNAGMMNT PPTTNQGNST IHASDVTMSG GSDSLDEIIQ QNLDEMHRRR SVPQPYGGQT 

       130        140        150        160        170        180 
RRLSMFDYAN PNDGFSDYQL DNMSGNYGDM TGGMGMSGHS SPYAGQNIMA MSDHSGGYSH 

       190        200        210        220        230        240 
MSPNVMGNMM TYPNLNMYHS PPIENPYSSA GLDTIRTDFS MDMNMDSGSV SAASVHPTPG 

       250        260        270        280        290        300 
LNKQDDEMMT MEQGFGGGDD ANASHQAQQN MGGLTPAMTP AMTPAMTPGV SNFAQGMATP 

       310        320        330        340        350        360 
VSQDAASTPA TTFQSPSLSA TTQTIRIGPP PPPSVTNAPT PAPFTSTPSG GGASQTKSIY 

       370        380        390        400        410        420 
SKSGFDMLRA LWYVASRKDP KLKLGAVDMS CAFVVCDVTL NDCPIIYVSD NFQNLTGYSR 

       430        440        450        460        470        480 
HEIVGRNCRF LQAPDGNVEA GTKREFVENN AVYTLKKTIA EGQEIQQSLI NYRKGGKPFL 

       490        500        510        520        530        540 
NLLTMIPIPW DTEEIRYFIG FQIDLVECPD AIIGQEGNGP MQVNYTHSDI GQYIWTPPTQ 

       550        560        570        580        590        600 
KQLEPADGQT LGVDDVSTLL QQCNSKGVAS DWHKQSWDKM LLENADDVVH VLSLKGLFLY 

       610        620        630        640        650        660 
LSPACKKVLE YDASDLVGTS LSSICHPSDI VPVTRELKEA QQHTPVNIVF RIRRKNSGYT 

       670        680        690        700        710        720 
WFESHGTLFN EQGKGRKCII LVGRKRPVFA LHRKDLELNG GIGDSEIWTK VSTSGMFLFV 

       730        740        750        760        770        780 
SSNVRSLLDL LPENLQGTSM QDLMRKESRA EFGRTIEKAR KGKIASCKHE VQNKRGQVLQ 

       790        800        810        820        830        840 
AYTTFYPGDG GEGQRPTFLL AQTKLLKASS RTLAPATVTV KNMSPGGVPL SPMKGIQTDS 

       850        860        870        880        890        900 
DSNTLMGGMS KSGSSDSTGA MVSARSSAGP GQDAALDADN IFDELKTTRC TSWQYELRQM 

       910        920        930        940        950        960 
EKVNRMLAEE LAQLLSNKKK RKRRKGGGNM VRDCANCHTR NTPEWRRGPS GNRDLCNSCG 

       970        980        990       1000       1010       1020 
LRWAKQTGRV SPRTSSRGGN GDSMSKKSNS PSHSSPLHRE VGNDSPSTTT ATKNSPSLRG 

      1030       1040       1050       1060       1070       1080 
SSTTAPGTIT TDSGPAVASS ASGTGSTTIA TSANSAASTV NALGPPATGP SGGSPAQHLP 

      1090       1100       1110       1120       1130       1140 
PHLQGTHLNA QAMQRVHQHK QHQQHQQQHQ QQHQQQHQQQ HQQLQQHQFN PPQSQPLLEG 

      1150       1160 
GSGFRGSGME MTSIREEMGE HQQGLSV

Q01371 in FASTA format

View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools